2-甲基-4-苯基-5-噻唑胺合成路线 （共 6 条）
反应条件
1: With sulfur; triethylamine in ethanol
T=0 - 70°C; 1 h;
2: With hydrogenchloride in ethanol; water
15 h;
参考文献
Nuevolution A/S
Patent: WO2009/152824 A1, 2009 ;
Location in patent: Page/Page column 215-216 ;
反应条件
(i) HBr, AcOH, (ii) NH3*H2O; Multistep reaction;
参考文献
Drach,B.S. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1974 , vol. 10, p. 810 - 812
Khimiya Geterotsiklicheskikh Soedinenii, 1974 , vol. 10, # 7 p. 928 - 931
反应条件
Lawesson's reagent in toluene
44 h; Reflux;
参考文献
ARRAY BIOPHARMA INC.; BRANDHUBER, Barbara, J.; JIANG, Yutong; KOLAKOWSKI, Gabrielle, R.; WINSKI, Shannon, L.
Patent: WO2014/78322 A1, 2014 ;
Location in patent: Paragraph 00516 ;
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 0.333333 h;
参考文献
Thompson, Mark J.; Chen, Beining
Tetrahedron Letters, 2008 , vol. 49, # 36 p. 5324 - 5327
反应条件
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / 20 °C
2: Lawesson's reagent / toluene / 44 h / |Reflux
View Scheme
参考文献
ARRAY BIOPHARMA INC.; BRANDHUBER, Barbara, J.; JIANG, Yutong; KOLAKOWSKI, Gabrielle, R.; WINSKI, Shannon, L.
Patent: WO2014/78322 A1, 2014 ;
反应条件
1: (i) THF, (ii) aq. Na2CO3
2: (i) HBr, AcOH, (ii) NH3*H2O
View Scheme
参考文献
Drach,B.S. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1974 , vol. 10, p. 810 - 812
Khimiya Geterotsiklicheskikh Soedinenii, 1974 , vol. 10, # 7 p. 928 - 931
