1: N-(2-bromopyridin-3-yl)trimethylacetamide With n-butyllithium in tetrahydrofuran
T=-78°C; 1 h;
2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran
T=-78 - 20°C;
3: With hydrogenchloride in methanol; water
T=100°C; 16 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2005/9967 A2, 2005 ;
Location in patent: Page/Page column 26 ;
WO 2005/009967 A2