2-(4-苯基噻唑-2-基)乙酸合成路线 （共 7 条）
反应条件
1: With water; sodium hydroxide in ethanol 1 h; Reflux; 2: With hydrogenchloride in ethanol; water
参考文献
Shionogi and Co., Ltd.
Patent: EP2351744 A1, 2011 ;
Location in patent: Page/Page column 60 ;
反应条件
hydrogenchloride 3 h; Heating;
参考文献
Smolii, O. B.; Panchishin, S. Ya.; Romanenko, E. A.; Drach, B. S.
Russian Journal of General Chemistry, 1995 , vol. 65, # 4.1 p. 521 - 524
Zhurnal Obshchei Khimii, 1995 , vol. 65, # 4 p. 583 - 586
反应条件
1: 79 percent / acetonitrile / 72 h / 20 °C 2: 45 percent / 36percent aq. HCl / 3 h / Heating View Scheme
参考文献
Smolii, O. B.; Panchishin, S. Ya.; Romanenko, E. A.; Drach, B. S.
Russian Journal of General Chemistry, 1995 , vol. 65, # 4.1 p. 521 - 524
Zhurnal Obshchei Khimii, 1995 , vol. 65, # 4 p. 583 - 586
反应条件
1.1: copper dichloride; isopentyl nitrite / acetonitrile / 3 h / 50 °C 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C 2.2: 1 h / 0 °C 3.1: sodium hydroxide; water / ethanol / 1 h / Reflux View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2351744 A1, 2011 ;
反应条件
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C 1.2: 1 h / 0 °C 2.1: sodium hydroxide; water / ethanol / 1 h / Reflux View Scheme
参考文献
Shionogi and Co., Ltd.
Patent: EP2351744 A1, 2011 ;
参考文献
Ohtsuka; Miyasaka; Arakawa
Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 12 p. 3254 - 3265
反应条件
1: (i) NaH, benzene, (ii) /BRN= 4050648/, DMF 2: aq. KOH View Scheme
参考文献
Ohtsuka; Miyasaka; Arakawa
Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 12 p. 3254 - 3265
