1-(2-乙基丁基)环己烷羧酸合成路线 （共 13 条）
反应条件
1: With potassium tert-butylate; water in tetrahydrofuran
T=54°C; 20 h;
2: With sulfuric acid in water
pH=1; Cooling with ice;
参考文献
Lohri, Bruno
Patent: US2009/312569 A1, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
1: With potassium tert-butylate; water in tetrahydrofuran
T=54°C; 20 h;
2: With sulfuric acid in water
pH=1; Cooling with ice;
参考文献
Lohri, Bruno
Patent: US2009/312569 A1, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
sulfuric acid; acetic acid
T=95°C; 22 h;
参考文献
Lohri, Bruno
Patent: US2009/312569 A1, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
1: cyclohexanecarboxylic acid Na-salt With n-butyllithium; diethylamine in tetrahydrofuran; hexane
T=20°C; 4.5 h;
2: 1-bromo-2-ethyl butane With n-butyllithium in tetrahydrofuran; hexane
T=10 - 20°C; 21.5 h;
3: With hydrogenchloride in water
pH=1 - 2; Product distribution / selectivity;
参考文献
F. Hoffmann-La Roche AG
Patent: EP1935867 A1, 2008 ;
Location in patent: Page/Page column 5; 6 ;
反应条件
1: cyclohexanecarboxylic acid With sodium hydride in tetrahydrofuran
T=0 - 20°C; 1.33333 h;
2: With n-butyllithium; diethylamine in tetrahydrofuran; hexane
T=20°C; 4 h;
3: 1-bromo-2-ethyl butane With hydrogenchloride; n-butyllithium
Product distribution / selectivity; more than 3 stages;
参考文献
F. Hoffmann-La Roche AG
Patent: EP1935867 A1, 2008 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
1: With acetic acid; sodium iodide
T=20 - 100°C;
2: With water; hydrogen bromide
T=100°C; 28.5 h; Product distribution / selectivity;
参考文献
Lohri, Bruno
Patent: US2009/312569 A1, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
nitrosyl-sulphuric acid; sulfuric acid; water
T=50 - 64°C; 2 h; Inert atmosphere;
参考文献
Harnett, Gerard John; Hayes, John; Reents, Reinhard; Smith, Dennis A.; Walsh, Andrew
Patent: US2012/71683 A1, 2012 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1: cyclohexanecarboxylic acid Li-salt With n-butyllithium; diethylamine in tetrahydrofuran; hexane
T=20°C; 4.5 h;
2: 1-bromo-2-ethyl butane in tetrahydrofuran; hexane
T=10 - 20°C; 19.5 h;
3: With hydrogenchloride in water
pH=2; Product distribution / selectivity;
参考文献
F. Hoffmann-La Roche AG
Patent: EP1935867 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
1: cyclohexanecarboxylic acid Na-salt With n-butyllithium; diethylamine in tetrahydrofuran; hexane
T=20°C; 4.5 h;
2: toluene-4-sulfonic acid 2-ethyl-butyl ester in tetrahydrofuran; hexane
T=10 - 20°C; 19.5 h;
3: With hydrogenchloride in water
Product distribution / selectivity;
参考文献
F. Hoffmann-La Roche AG
Patent: EP1935867 A1, 2008 ;
Location in patent: Page/Page column 10 ;
反应条件
1: cyclohexanecarboxylic acid Na-salt With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
2: neopentyl iodide With n-butyllithium in tetrahydrofuran; hexane
3: With hydrogenchloride in water
Product distribution / selectivity;
参考文献
F. Hoffmann-La Roche AG
Patent: EP1935867 A1, 2008 ;
Location in patent: Page/Page column 5 ;
