5-(2-吡啶基)-1,2-二氢吡啶-2-酮合成路线 （共 12 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in water; acetonitrile T=75°C; Suzuki coupling;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5774 - 5777
反应条件
water T=95 - 100°C; 4 h; Acidic conditions;
参考文献
EP2586777 A1, ;
Paragraph 0064 ;
反应条件
1: With hydrogenchloride; water in toluene T=100°C; 10 h; 2: With potassium carbonate in water pH=7 - 8; Product distribution / selectivity;
参考文献
EP2123639 A1, ;
Page/Page column 17 ;
反应条件
1: With hydrogenchloride; water in toluene T=100°C; 10 h; 2: With potassium carbonate in water pH=7 - 8; Product distribution / selectivity;
参考文献
EP2123639 A1, ;
Page/Page column 15 ;
反应条件
ammonium acetate; acetic acid in isopropyl alcohol T=100°C; 11 h; Product distribution / selectivity;
参考文献
EP2123639 A1, ;
Page/Page column 17 ;
反应条件
hydrogenchloride; sodium hydroxide
反应条件
1.1: 3 h / 60 °C / Inert atmosphere 2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere 3.1: water; hydrogen bromide / 3 h / 110 °C 3.2: pH 11 / Cooling with ice View Scheme
参考文献
Synthesis, , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere 2.1: water; hydrogen bromide / 3 h / 110 °C 2.2: pH 11 / Cooling with ice View Scheme
参考文献
Synthesis, , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere 2.1: water; hydrogen bromide / 3 h / 110 °C 2.2: pH 11 / Cooling with ice View Scheme
参考文献
Synthesis, , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1: potassium carbonate; palladium diacetate; triphenylphosphine / water; ethylene glycol dimethyl ether / 5.67 h / |Reflux 2: hydrogenchloride / water / 3 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10584 - 10600
