2-氨基-3-碘-5-溴吡啶合成路线 （共 13 条）
反应条件
iodine; periodic acid in acetonitrile Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 38 p. 10093 - 10096
Angew. Chem., , vol. 52, # 38 p. 10093 - 10096,4
反应条件
N-bromosuccinmide in dichloromethane T=20°C; 3 h;
参考文献
Organic Letters, , vol. 16, # 3 p. 708 - 711
反应条件
sodium hydroxide; sulfuric acid; iodine in diethyl ether; water; acetic acid; ethyl acetate
反应条件
in dichloromethane 17 h; Polystyrene;
参考文献
US2008/261921 A1, ;
Page/Page column 70-71 ;
US 20080261921 A1
反应条件
1: N-bromosuccinmide / acetonitrile / 2 h / 20 °C 2: iodine; KIO3; sulfuric acid; acetic acid / water / 8 h / 80 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 12, # 2 p. 307 - 315
反应条件
1: With sulfuric acid T=20°C; 2 h; Cooling with ice; 2: With sodium nitrite T=20°C; 72 h;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10584 - 10600
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine T=20°C; Sonogashira Cross-Coupling; 1 h; Inert atmosphere;
参考文献
Barl, Nadja M.; Sansiaume-Dagousset, Elodie; Karaghiosoff, Konstantin; Knochel, Paul
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10093 - 10096
Angew. Chem., 2013 , vol. 52, # 38 p. 10093 - 10096,4
反应条件
1: With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate in N,N-dimethyl-formamide T=110°C; 4 h; Inert atmosphere; 2: With hydrogenchloride in ethanol T=65°C; 16 h; 3: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ABEYWARDANE, Asitha; FARMER, Bennett; FARROW, Neil Alexander; GAO, Donghong A.; HEIM-RIETHER, Alexander; KEENAN, Lana Louise Smith; MUGGE, Ingo Andreas; TAYLOR, Steven John; XIONG, Zhaoming; YU, Yang; ZHANG, Qiang
Patent: WO2010/45188 A1, 2010 ;
Location in patent: Page/Page column 92; 93 ;
WO 2010/045188 A1
反应条件
1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 0 - 20 °C 2: potassium tert-butylate / tert-butyl alcohol / 1 h / 85 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DYKE, Hazel Joan; GAZZARD, Lewis J.; WILLIAMS, Karen
Patent: WO2011/73263 A1, 2011 ;
WO 2011/073263 A1
反应条件
1: lithium hydroxide hydrate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide / 18 h / 70 °C 2: hydrogenchloride / water / 1 h / 50 °C View Scheme
参考文献
Barl, Nadja M.; Sansiaume-Dagousset, Elodie; Karaghiosoff, Konstantin; Knochel, Paul
Angewandte Chemie - International Edition, 2013 , vol. 52, # 38 p. 10093 - 10096
Angew. Chem., 2013 , vol. 52, # 38 p. 10093 - 10096,4
