2-羟基-3-溴-5-乙酸酯吡啶合成路线 （共 9 条）
反应条件
1: With bromine; acetic acid T=60°C; 2: With sodium hydrogencarbonate; sodium hydroxide T=18 - 26°C; pH=~ 7;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/106885 A1, 2009 ;
Location in patent: Page/Page column 296-297 ;
WO 2009/106885 A1
反应条件
hydrogenchloride 48 h; Reflux;
参考文献
CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, SeoHee; Oh, Jung Taek; Lee, JaeKwang; Lee, JaeWon; Bae, Suyeal; Ha, Nina; Lee, Sera
Patent: US2014/31335 A1, 2014 ;
Location in patent: Paragraph 0042; 0562; 0563 ;
反应条件
1: bromine / water / 20 °C 2: hydrogenchloride / 48 h / Reflux View Scheme
参考文献
CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, SeoHee; Oh, Jung Taek; Lee, JaeKwang; Lee, JaeWon; Bae, Suyeal; Ha, Nina; Lee, Sera
Patent: US2014/31335 A1, 2014 ;
参考文献
v. Pechmann
Chemische Berichte, 1884 , vol. 17, p. 2399
Chemische Berichte, 1885 , vol. 18, p. 318
反应条件
1: 5-bromo-6-hydroxy-3-pyridinecarboxylic acid With phosphorus pentachloride; trichlorophosphate 2: methanol
参考文献
Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Hebeisen, Paul; Nettekoven, Matthias; Sander, Ulrike Obst; Panousis, Constantinos G.; Roever, Stephan
Patent: US2008/85906 A1, 2008 ;
Location in patent: Page/Page column 15 ;
参考文献
v. Pechmann
Chemische Berichte, 1884 , vol. 17, p. 2399
Chemische Berichte, 1885 , vol. 18, p. 318
反应条件
triethyloxonium tetra-fluoroborate
参考文献
CHONG KUN DANG PHARMACEUTICAL CORP.; Lee, SeoHee; Oh, Jung Taek; Lee, JaeKwang; Lee, JaeWon; Bae, Suyeal; Ha, Nina; Lee, Sera
Patent: US2014/31335 A1, 2014 ;
Location in patent: Paragraph 0042; 0562; 0563 ;
反应条件
1: 5-bromo-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid methyl ester With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 17 h;
参考文献
AMGEN INC.
Patent: WO2007/62007 A1, 2007 ;
Location in patent: Page/Page column 82-83 ;
WO 2007/062007 A1
反应条件
tetrabutylammomium bromide; phosphorus pentoxide in toluene
5 h; Reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/106885 A1, 2009 ;
Location in patent: Page/Page column 297 ;
WO 2009/106885 A1
