3-溴-1-苯基-5-(吡啶-2-基)吡啶-2(1H)-酮合成路线 （共 9 条）
反应条件
caesium carbonate; palladium dichloride in N,N-dimethyl-formamide T=80°C; Suzuki-Miyaura Coupling; 6 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10584 - 10600
反应条件
copper(l) iodide; palladium diacetate; potassium carbonate; triphenylphosphine in ethylene glycol dimethyl ether T=70 - 95°C; Suzuki coupling; 5.5 h; Inert atmosphere;
参考文献
Synthesis, , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1.1: 3 h / 60 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere
3.1: water; hydrogen bromide / 3 h / 110 °C
3.2: pH 11 / Cooling with ice
4.1: pyridine; copper diacetate / N,N-dimethyl-formamide / 16 h
5.1: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C
View Scheme
参考文献
McElhinny Jr., Charles J.; Carroll; Lewin, Anita H.
Synthesis, 2012 , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere
2.1: water; hydrogen bromide / 3 h / 110 °C
2.2: pH 11 / Cooling with ice
3.1: pyridine; copper diacetate / N,N-dimethyl-formamide / 16 h
4.1: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C
View Scheme
参考文献
McElhinny Jr., Charles J.; Carroll; Lewin, Anita H.
Synthesis, 2012 , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1: pyridine; copper diacetate / N,N-dimethyl-formamide / 16 h
2: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C
View Scheme
参考文献
McElhinny Jr., Charles J.; Carroll; Lewin, Anita H.
Synthesis, 2012 , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1.1: water; hydrogen bromide / 3 h / 110 °C
1.2: pH 11 / Cooling with ice
2.1: pyridine; copper diacetate / N,N-dimethyl-formamide / 16 h
3.1: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C
View Scheme
参考文献
McElhinny Jr., Charles J.; Carroll; Lewin, Anita H.
Synthesis, 2012 , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere
2.1: water; hydrogen bromide / 3 h / 110 °C
2.2: pH 11 / Cooling with ice
3.1: pyridine; copper diacetate / N,N-dimethyl-formamide / 16 h
4.1: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C
View Scheme
参考文献
McElhinny Jr., Charles J.; Carroll; Lewin, Anita H.
Synthesis, 2012 , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1: pyridine; copper diacetate / N,N-dimethyl-formamide / 16 h
2: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C
View Scheme
参考文献
McElhinny Jr., Charles J.; Carroll; Lewin, Anita H.
Synthesis, 2012 , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1: potassium carbonate; palladium diacetate; triphenylphosphine / water; ethylene glycol dimethyl ether / 5.67 h / |Reflux
2: hydrogenchloride / water / 3 h / |Reflux
3: copper diacetate; pyridine / N,N-dimethyl-formamide / 20 °C
4: N-bromosuccinmide / N,N-dimethyl-formamide / 2.5 h / 20 °C
View Scheme
参考文献
Hibi, Shigeki; Ueno, Koshi; Nagato, Satoshi; Kawano, Koki; Ito, Koichi; Norimine, Yoshihiko; Takenaka, Osamu; Hanada, Takahisa; Yonaga, Masahiro
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10584 - 10600
