3-(4-甲氧基苯基)-1,2,3-恶二唑-3-鎓-5-醇合成路线 （共 5 条）
反应条件
acetic anhydride
T=20°C; 12 h; Darkness;
参考文献
Savaliya, Piyush P.; Akbari, Vikunjana K.; Modi, Jigisha A.; Patel, Keshav C.
Medicinal Chemistry Research, 2013 , vol. 22, # 12 p. 5789 - 5797
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; acetic anhydride; sodium nitrite in dichloromethane
T=0 - 5°C; 10.5 h;
参考文献
Azarifar, Davood; Ghasemnejad-Bosra, Hassan; Tajbaksh, Mahmood; Habibzadeh, Setareh
Heterocycles, 2007 , vol. 71, # 8 p. 1815 - 1819
反应条件
1.1: sodium acetate / ethanol / Reflux
2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 2 °C
2.2: 20 °C / pH 3 - 4
3.1: sodium nitrite / water / 0.33 h / 0 °C
4.1: acetic anhydride / 5 h / 100 °C
View Scheme
参考文献
Fang, Yuesi; Wu, Chunrui; Larock, Richard C.; Shi, Feng
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8840 - 8851
反应条件
1.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 2 °C
1.2: 20 °C / pH 3 - 4
2.1: sodium nitrite / water / 0.33 h / 0 °C
3.1: acetic anhydride / 5 h / 100 °C
View Scheme
参考文献
Fang, Yuesi; Wu, Chunrui; Larock, Richard C.; Shi, Feng
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8840 - 8851
反应条件
in anhydrous xylene
24 h; Reflux; regioselective reaction;
参考文献
Browne, Duncan L.; Taylor, John B.; Plant, Andrew; Harrity, Joseph P. A.
Journal of Organic Chemistry, 2010 , vol. 75, # 3 p. 984 - 987
