4,7-二氯-2-甲基喹唑啉合成路线 （共 7 条）
反应条件
N,N-diethylaniline; trichlorophosphate in benzene 16 h; RefluxInert atmosphere;
参考文献
Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J.
European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
反应条件
1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere 2: water; sodium hydroxide / 1 h / Reflux; Inert atmosphere 3: N,N-diethylaniline; trichlorophosphate / benzene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J.
European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
反应条件
1: water; sodium hydroxide / 1 h / Reflux; Inert atmosphere 2: N,N-diethylaniline; trichlorophosphate / benzene / 16 h / Reflux; Inert atmosphere View Scheme
参考文献
Fleming, William J.; Mueller-Bunz, Helge; Guiry, Patrick J.
European Journal of Organic Chemistry, 2010 , # 31 p. 5996 - 6004
反应条件
1: 78.4 percent / 25percent aq. NH3 / 1.) 0-5 deg C, 2) 48-50 deg C, 10 h 2: dimethylaniline, POCl3 / toluene / 6 h / 83 - 87 °C View Scheme
参考文献
Yakhontov, L. N.; Zhikhareva, G. P.; Mastafanova, L. I.; Evstratova, M. I.; Pershin, G. N.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 34 - 45
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 38 - 49
反应条件
1: 88 percent / 25percent aq. NH3 / 6 h / 126 - 129 °C / 3800 - 9120 Torr 2: 3 h / 110 - 120 °C 3: 78.4 percent / 25percent aq. NH3 / 1.) 0-5 deg C, 2) 48-50 deg C, 10 h 4: dimethylaniline, POCl3 / toluene / 6 h / 83 - 87 °C View Scheme
参考文献
Yakhontov, L. N.; Zhikhareva, G. P.; Mastafanova, L. I.; Evstratova, M. I.; Pershin, G. N.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 34 - 45
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 38 - 49
反应条件
1: 68 percent / 25percent aq. NH3, cupric acetate / 10 h / 126 - 129 °C 2: 3 h / 110 - 120 °C 3: 78.4 percent / 25percent aq. NH3 / 1.) 0-5 deg C, 2) 48-50 deg C, 10 h 4: dimethylaniline, POCl3 / toluene / 6 h / 83 - 87 °C View Scheme
参考文献
Yakhontov, L. N.; Zhikhareva, G. P.; Mastafanova, L. I.; Evstratova, M. I.; Pershin, G. N.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 34 - 45
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 38 - 49
反应条件
1: 3 h / 110 - 120 °C 2: 78.4 percent / 25percent aq. NH3 / 1.) 0-5 deg C, 2) 48-50 deg C, 10 h 3: dimethylaniline, POCl3 / toluene / 6 h / 83 - 87 °C View Scheme
参考文献
Yakhontov, L. N.; Zhikhareva, G. P.; Mastafanova, L. I.; Evstratova, M. I.; Pershin, G. N.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 34 - 45
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 38 - 49
