5-(羟甲基)-2',3'-O-(异丙亚基)尿苷合成路线 （共 6 条）
反应条件
water; acetic acid Hydrolysis; 5 h; Heating;
参考文献
Gavriliu; Fossey; Fontaine; Benzaria; Ciurea; Delbederi; Lelong; Laduree; Aubertin; Kirn
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 5-6 p. 1017 - 1031
反应条件
1.1: AcOH / H2O / 5 h / Heating
2.1: 169 mg / imidazole; DMAP / dimethylformamide / 2 h
3.1: NaOH / dimethylsulfoxide; H2O / 0.33 h / 20 °C
3.2: 41 percent / dimethylsulfoxide; H2O / 1.5 h
4.1: 77 percent / AIBN; Bu3SnH / toluene / 3 h / Heating
5.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h
View Scheme
参考文献
Chung, Raymond; Anderson, Karen S.
Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8361 - 8363
反应条件
<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) ZnCl<sub>2</sub>, 2.) NaCNBH<sub>3</sub> / 1.) MeOH, RT, 20 min, 2.) MeOH, RT, 36 h<br />2: 9 percent / 2.67 h / 195 - 200 °C / 5 Torr<br />3: 80 percent / aq. KOH / 50 °C<br /> <br />
参考文献
Wang; Kagel; Mertes; Bowman-James Bioorganic Chemistry, 1994 , vol. 22, # 4 p. 405 - 420
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: 9 percent / 2.67 h / 195 - 200 °C / 5 Torr<br />2: 80 percent / aq. KOH / 50 °C<br /> <br />
参考文献
Wang; Kagel; Mertes; Bowman-James Bioorganic Chemistry, 1994 , vol. 22, # 4 p. 405 - 420
反应条件
<b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '11342937', constants.ctx, '0')">potassium hydroxide</a> <br />0.05 h; microwave irradiation; <br />
参考文献
Abdel-Rahman, Adel A.-H.; El Ashry, El Sayed H. Synlett, 2002 , # 12 p. 2043 - 2044
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: 73 percent / p-toluenesulfonic acid monohydrate / acetone<br />2: 31 percent / KOH / H<sub>2</sub>O / 48 h / 60 °C<br /> <br />
参考文献
Chung, Raymond; Anderson, Karen S. Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8361 - 8363
