1: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 2: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 3: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 4: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: 98 percent / KOH / dimethylsulfoxide / 2 h 2: 67.5 percent / 1N HCl / dioxane / 1.5 h / 90 °C View Scheme