2-(氯甲基)-4(3H)-喹唑啉酮合成路线 （共 17 条）
反应条件
hydrogenchloride in 1,4-dioxane; water T=20 - 80°C; 24 h;
参考文献
MYRIAD GENETICS, INC.; CYTOVIA, INC.
Patent: WO2006/74187 A2, 2006 ;
Location in patent: Page/Page column 54 ;
WO 2006/074187 A2
反应条件
hydrogenchloride in water 0.5 h; Microwave irradiation;
参考文献
Jain, Kishor S.; Bariwal, Jitender B.; Phoujdar, Manisha S.; Nagras, Madhuri A.; Amrutkar, Rakesh D.; Munde, Manoj K.; Tamboli, Riyaj S.; Khedkar, Samrat A.; Khiste, Rahul H.; Vidyasagar, Nikhil C.; Dabholkar, Vinit V.; Kathiravan
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 178 - 185
反应条件
potassium carbonate in water T=80°C; 1 h; Microwave irradiation;
参考文献
Kabri, Youssef; Gellis, Armand; Vanelle, Patrice
European Journal of Organic Chemistry, 2009 , # 24 p. 4059 - 4066
反应条件
urea hydrogen peroxide addition compound; potassium carbonate in water; acetone T=70°C; Radziszewski's reaction; 1.5 h; Microwave irradiation;
参考文献
Kabri; Gellis; Vanelle
Green Chemistry, 2009 , vol. 11, # 2 p. 201 - 208
反应条件
1: chloroacetonitrile With sodium in methanol T=25°C; 0.666667 h; Inert atmosphere; 2: anthranilic acid in methanol T=25°C; 2 h; Inert atmosphere;
参考文献
Li, Hong-Ze; He, Hai-Yun; Han, Yuan-Yuan; Gu, Xin; He, Lin; Qi, Qing-Rong; Zhao, Ying-Lan; Yang, Li
Molecules, 2010 , vol. 15, # 12 p. 9473 - 9485
反应条件
1: T=50°C; 0.0833333 h; Microwave irradiation; 2: With potassium carbonate in water T=80°C; 1.5 h; Microwave irradiation;
参考文献
Kabri, Youssef; Azas, Nadine; Dumetre, Aurelien; Hutter, Sebastien; Laget, Michele; Verhaeghe, Pierre; Gellis, Armand; Vanelle, Patrice
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 2 p. 616 - 622
反应条件
1: 71 percent / benzene; pyridine 2: 82 percent / various solvent(s) / 8 h / Heating View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 1 p. 40 - 44
反应条件
1: 54 percent / Py / dimethylformamide / 20 °C 2: 55 percent / urea hydrogen peroxide; K2CO3 / acetone; H2O / 30 h / 84 °C View Scheme
参考文献
Synthetic Communications, , vol. 28, # 24 p. 4547 - 4559
反应条件
1: 95 percent / benzene / Heating 2: 38 percent / NH3 / methanol / 72 h / Ambient temperature; N-(chloroacetyl)anthranilate intermediate; 1,4-benzodiazepine production for N-(bromoacetyl)anthranilate; no ring closure teactions for 3-haloacetamidocrotonates under analoguos conditions View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 26, p. 1807 - 1810
反应条件
pyridine; N-chloro-succinimide in chloroform 1 h;
参考文献
Journal of Chemical Research, Miniprint, , # 7 p. 1560 - 1575
