2-(氯甲基)-4(3H)-喹唑啉酮合成路线 （共 17 条）
反应条件
ammonia in methanol 72 h; Ambient temperature;
参考文献
Cho, Nam Sook; Song, Ki Youn
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1807 - 1810
反应条件
0.05 h; microwave irradiation;
参考文献
Rahimizadeh; Tavallai; Bakavoli
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 3 p. 679 - 681
反应条件
triethylamine in ethanol 20 h; Heating;
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
反应条件
N-benzyl-N,N,N-triethylammonium chloride; NAF in dimethyl sulfoxide T=130 - 140°C;
参考文献
Kathiravan, Muthu K.; More, Kapil D.; Raskar, Vikas K.; Jain, Kishor S.; Maheshwar, Mukta; Gadhwe, Sandeep; Jain, Dilpesh P.; Nagras, Madhuri A.; Phoujdar, Manisha S.
Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4286 - 4292
反应条件
potassium hydroxide in tetrahydrofuran; water T=60°C; 0.5 h; Microwave irradiation;
参考文献
Kabri; Gellis; Vanelle
Green Chemistry, 2009 , vol. 11, # 2 p. 201 - 208
反应条件
1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene T=65°C; 2: With sodium hydrogencarbonate in water; toluene
参考文献
MYRIAD PHARMACEUTICALS, INC.; ANDERSON, Mark, B.; KIM, In, Chul
Patent: WO2010/6115 A1, 2010 ;
Location in patent: Page/Page column 5; 6 ;
反应条件
sodium hydroxide in water 1 h; RefluxInert atmosphere;
参考文献
Li, Hong-Ze; He, Hai-Yun; Han, Yuan-Yuan; Gu, Xin; He, Lin; Qi, Qing-Rong; Zhao, Ying-Lan; Yang, Li
Molecules, 2010 , vol. 15, # 12 p. 9473 - 9485
