6'-甲氧基-2,3'-联吡啶合成路线 （共 14 条）
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=120°C; Stille coupling; 3 h; Inert atmosphere;
2: With sodium hydrogencarbonate in diethyl ether; water
参考文献
McElhinny Jr., Charles J.; Carroll; Lewin, Anita H.
Synthesis, 2012 , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
反应条件
1: 3 h / 60 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere
View Scheme
参考文献
McElhinny Jr., Charles J.; Carroll; Lewin, Anita H.
Synthesis, 2012 , vol. 44, # 1 art. no. M92511SS, p. 57 - 62
参考文献
Gleave, Robert J.; Beswick, Paul J.; Brown, Andrew J.; Giblin, Gerard M.P.; Haslam, Carl P.; Livermore, David; Moses, Andrew; Nicholson, Neville H.; Page, Lee W.; Slingsby, Brian; Swarbrick, Martin E.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6578 - 6581
反应条件
1.1: water; hydrogen bromide / 3 h / 110 °C
1.2: pH 11 / Cooling with ice
2.1: pyridine; copper diacetate / N,N-dimethyl-formamide / 16 h
3.1: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 20 °C
View Scheme
参考文献
Hibi, Shigeki; Ueno, Koshi; Nagato, Satoshi; Kawano, Koki; Ito, Koichi; Norimine, Yoshihiko; Takenaka, Osamu; Hanada, Takahisa; Yonaga, Masahiro
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10584 - 10600
