air in methanol; acetonitrile T=80°C; 11 h;

1: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C / |Inert atmosphere 2: palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / toluene; tetrahydrofuran / 2 h / 65 °C / |Inert atmosphere 3: diisobutylaluminium hydride / dichloromethane / 1 h / -78 °C / |Inert atmosphere 4: perchloric acid / acetic acid; water / 9 h / 20 °C / |Inert atmosphere 5: 2,6-di-tert-butyl-pyridine / acetonitrile / 1.17 h / |Inert atmosphere 6: air / methanol; acetonitrile / 11 h / 80 °C View Scheme

1: bromine / tetrachloromethane / 0.08 h / -10 °C / |Inert atmosphere 2: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C / |Inert atmosphere 3: palladium diacetate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / toluene; tetrahydrofuran / 2 h / 65 °C / |Inert atmosphere 4: diisobutylaluminium hydride / dichloromethane / 1 h / -78 °C / |Inert atmosphere 5: perchloric acid / acetic acid; water / 9 h / 20 °C / |Inert atmosphere 6: 2,6-di-tert-butyl-pyridine / acetonitrile / 1.17 h / |Inert atmosphere 7: air / methanol; acetonitrile / 11 h / 80 °C View Scheme