5-溴-3-氯-2-氟吡啶合成路线 （共 2 条）
反应条件
pyridine; hydrogen fluoride; sodium nitrite T=20°C; Cooling with ice;
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: EP2221301 A1, 2010 ;
Location in patent: Page/Page column 46 ;
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=80°C; 2 h; Inert atmosphere;
参考文献
PFIZER LIMITED; BELL, Andrew Simon; DE GROOT, Marcel John; LEWTHWAITE, Russell Andrew; MARSH, Ian Roger; SCIAMMETTA, Nunzio; STORER, Robert Ian; SWAIN, Nigel Alan
Patent: WO2012/95781 A1, 2012 ;
Location in patent: Page/Page column 102 ;
WO 2012/095781 A1
