5-氨基-2-氯-3-甲基吡啶合成路线 （共 15 条）
反应条件
hydrogen in tetrahydrofuran T=37°C; P=2250.23 Torr; 8 h; chemoselective reaction;
参考文献
Kasparian, Annie J.; Savarin, Cecile; Allgeier, Alan M.; Walker, Shawn D.
Journal of Organic Chemistry, 2011 , vol. 76, # 23 p. 9841 - 9844
反应条件
acetic acid in ethyl acetate
参考文献
Abbott Laboratories
Patent: US5733912 A1, 1998 ;
参考文献
Abbott Laboratories
Patent: US6133253 A1, 2000 ;
反应条件
ammonium chloride; iron in methanol
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1803709 A1, 2007 ;
反应条件
hydrogenchloride; sodium nitrite in water T=0 - 90°C; 0.833333 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/123668 A1, 2005 ;
Location in patent: Page/Page column 46-47 ;
WO 2005/123668 A1
反应条件
sodium hydroxide; acetic acid; sodium nitrite in hydrogenchloride; water
参考文献
Merck and Co., Inc.
Patent: US4374140 A1, 1983 ;
US 4374140 A
反应条件
hydrogenchloride; HPF6; sodium nitrite Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
参考文献
Ife; Catchpole; Durant; Ganellin; Harvey; Meeson; Owen; Parsons; Slingsby; Theobald
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 3 p. 249 - 258
反应条件
hydrogenchloride; HPF6; sodium nitrite Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite T=50°C; 0.166667 h;
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
