5-氨基-2-氯-3-甲基吡啶合成路线 （共 15 条）
反应条件
Ki; sodium thiosulfate in ethylene glycol dimethyl ether; acetonitrile; pentane
参考文献
Abbott Laboratories
Patent: US5733912 A1, 1998 ;
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
1: 1.)NaNO2/12N HCl 2.)HPF6
2: 95 percent / NaH / dimethylformamide / Ambient temperature; overnight
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
1: 1.)NaNO2/12N HCl 2.)HPF6
2: 95 percent / NaH / dimethylformamide / Ambient temperature; overnight
3: 35 percent / KMnO4 / H2O / 1 h / Heating
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
1: 1.)NaNO2/12N HCl 2.)HPF6
2: 95 percent / NaH / dimethylformamide / Ambient temperature; overnight
3: 35 percent / KMnO4 / H2O / 1 h / Heating
4: SOCl2 / 3 h / Heating
5: NH3*H2O / 0.25 h / 0 - 4 °C
6: 86 percent / triflic anhydride/triphenylphosphine oxide / CH2Cl2 / Ambient temperature; overnight
7: 70 percent / pyridine hydrochloride / 2 h / 200 °C
View Scheme
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
