2-氯-3-甲基-5-氟吡啶合成路线 （共 5 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1 h; 2: With hydrogenchloride; water in tetrahydrofuran 0.5 h;
参考文献
GLAXO GROUP LIMITED; ALVARO, Giuseppe; AMANTINI, David
Patent: WO2010/72722 A1, 2010 ;
Location in patent: Page/Page column 26 ;
WO 2010/072722 A1
参考文献
Ife; Catchpole; Durant; Ganellin; Harvey; Meeson; Owen; Parsons; Slingsby; Theobald
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 3 p. 249 - 258
反应条件
hydrogenchloride; HPF6; sodium nitrite Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ponticello, Gerald S.; Engelhardt, Edward L.; Freedman, Mark B.; Baldwin, John J.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 445 - 448
反应条件
1: With N-(diphenylmethylene)amine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); rac-BINAP in toluene T=80°C; 1 h; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C; 1.5 h; 3: With sodium hydrogencarbonate in tetrahydrofuran; water
参考文献
ALVARO, GIUSEPPE; AMANTINI, DAVID; BELVEDERE, SANDRO
Patent: US2009/22670 A1, 2009 ;
Location in patent: Page/Page column 20 ;
US 20090022670 A1
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.5 h / 120 °C / microwave irradiation 2.1: hydrogenchloride; water / 2 h / 120 °C / Sealed tube 2.3: pH 2 View Scheme
参考文献
NOVARTIS AG; HURTH, Konstanze; LUEOEND, Rainer Martin; MACHAUER, Rainer; NEUMANN, Ulf; RUEEGER, Heinrich; SCHAEFER, Michael; TINTELNOT-BLOMLEY, Marina; VEENSTRA, Siem Jacob; VOEGTLE, Markus
Patent: WO2012/95463 A1, 2012 ;
