2-氯-5-氟烟酸合成路线

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VERTEX PHARMACEUTICALS INCORPORATED
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WO 2008/112642 A1

139911-30-12-氯-5-氟烟酸乙酯

38186-88-82-氯-5-氟烟酸

参考文献

Zhang, Yinsheng; Jian, Zhigang; Stolle, Wayne T.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 7 p. 382 - 386

1316084-72-6

38186-88-82-氯-5-氟烟酸

参考文献

Zhang, Yinsheng; Jian, Zhigang; Stolle, Wayne T.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 7 p. 382 - 386

38186-88-82-氯-5-氟烟酸

791644-48-92-氯-5-氟烟腈

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VERTEX PHARMACEUTICALS INCORPORATED; CHARIFSON, Paul, S.; CLARK, Michael, P.; BANDARAGE, Upul, K.; DAVIES, Ioana; DUFFY, John, P.; GAO, Huai; FENG, Jun; LIANG, Jianglin; KENNEDY, Joseph, M.; LEDEBOER, Mark, W.; LEDFORD, Brian; MALTAIS, Francois; PEROLA, Emanuele
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38186-88-82-氯-5-氟烟酸

884495-37-82-氯-5-氟-3-氨基吡啶

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AMGEN INC.; Allen, Jennifer R.; Amegadzie, Albert; Andrews, Kristin L.; Brown, James; Chen, Jian J.; Chen, Ning; Harrington, Essa Hu; Liu, Qingyian; Nguyen, Thomas T.; Pickrell, Alexander J.; Qian, Wenyuan; Rumfelt, Shannon; Rzasa, Robert M.; Yuan, Chester Chenguang; Zhong, Wenge
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38186-88-82-氯-5-氟烟酸

884494-33-12-氯-5-氟-3-碘吡啶

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Zhang, Yinsheng; Jian, Zhigang; Stolle, Wayne T.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 7 p. 382 - 386

38186-88-82-氯-5-氟烟酸+

74-88-4甲基碘

847729-27-5

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38186-88-82-氯-5-氟烟酸+

18107-18-1三甲基硅烷化重氮甲烷

847729-27-5

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67-56-1甲醇+

38186-88-82-氯-5-氟烟酸

847729-27-5

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PFIZER PRODUCTS INC.
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38186-88-82-氯-5-氟烟酸

1034667-22-5

参考文献

VERTEX PHARMACEUTICALS INCORPORATED; CHARIFSON, Paul, S.; CLARK, Michael, P.; BANDARAGE, Upul, K.; DAVIES, Ioana; DUFFY, John, P.; GAO, Huai; FENG, Jun; LIANG, Jianglin; KENNEDY, Joseph, M.; LEDEBOER, Mark, W.; LEDFORD, Brian; MALTAIS, Francois; PEROLA, Emanuele
Patent: WO2012/83117 A1, 2012 ;