反应条件
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere 1.2: 0.25 h / 0 °C 2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.75 h / 0 °C 3.1: hydrazine hydrate / butan-1-ol / 4.5 h / Reflux 4.1: tert.-butylnitrite; tribromo methane / 2 h / 61 - 90 °C View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; CHARIFSON, Paul, S.; CLARK, Michael, P.; BANDARAGE, Upul, K.; BETHIEL, Randy, S.; BOYD, Michael, J.; DAVIES, Iona; DENG, Hongbo; DUFFY, John, P.; FARMER, Luc, J.; GAO, Huai; GU, Wenxin; KENNEDY, Joseph, M.; LEDFORD, Brian; LEDEBOER, Mark, W.; MALTAIS, Francois; PEROLA, Emanuele; WANG, Tiansheng
Patent: WO2013/19828 A1, 2013 ;