2-氨基-5-甲基硫代-(1h)-吡咯-3,4-二羧酰胺合成路线 （共 12 条）
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) RT, 3 h 2: 76 percent / Raney Ni / ethanol / 2 h / Heating 4: 76 percent / BCl3 / CH2Cl2 / 4 h / -78 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) RT, 3 h 3: 63 percent / BCl3 / CH2Cl2 / 4 h / -78 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) 100 deg C, 18 h 2: 54 percent / Raney Ni / ethanol / 18 h / Heating 4: 88 percent / 80percent aq. AcOH / 4 h / 80 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) 100 deg C, 18 h 3: 76.6 percent / tosyl chloride, pyridine / Ambient temperature 4: 78 percent / 80percent aq. AcOH / 4 h / 80 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) RT, 3 h 3: 75 percent / tosyl chloride, pyridine / Ambient temperature 4: 79 percent / BCl3 / CH2Cl2 / 4 h / -78 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) 100 deg C, 18 h 3: 76 percent / 80percent aq. AcOH / 4 h / 80 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) RT, 3 h 3: 76 percent / tosyl chloride, pyridine / Ambient temperature 4: 62 percent / BCl3 / CH2Cl2 / 4 h / -78 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) 100 deg C, 18 h 2: 54 percent / Raney Ni / ethanol / 18 h / Heating 4: 85 percent / tosyl chloride, pyridine / Ambient temperature 5: 77 percent / 80percent aq. AcOH / 4 h / 80 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) RT, 3 h 2: 75 percent / Raney Ni / ethanol / 2 h / Heating 4: 71 percent / tosyl chloride, pyridine / Ambient temperature 5: 69 percent / BCl3 / CH2Cl2 / 4 h / -78 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
反应条件
1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) 100 deg C, 18 h 3: 58 percent / 80percent aq. AcOH / 4 h / 80 °C View Scheme
参考文献
Bennett, Sharon M.; Nguyen-Ba, Nghe; Ogilvie, Kelvin K.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2162 - 2173
