1-氟-3-碘-5-硝基苯合成路线 （共 15 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C;
参考文献
Muci, Alex; Lu, Pu-Ping; Morgan, Bradley P.; Morgans, JR., David J.
Patent: US2009/192168 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
hydrogenchloride in N-methyl-acetamide; ice-water
参考文献
Daiichi Pharmaceutical Co., Ltd.
Patent: US6169086 A, 2001 ;
反应条件
in N,N-dimethyl-formamide 3 h; Heating;
参考文献
Naito, Hiroyuki; Ohsuki, Satoru; Atsumi, Ryo; Minami, Megumi; Mochizuki, Mineko; Hirotani, Kenji; Kumazawa, Eiji; Ejima, Akio
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 2 p. 153 - 163
反应条件
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; tetra-(n-butyl)ammonium iodide; triethylamine / N,N-dimethyl-formamide / 70 °C / Inert atmosphere 2.1: borane-THF; cyclohexene / tetrahydrofuran / 0 - 20 °C 2.2: 0.25 h View Scheme
参考文献
Iwahashi, Maki; Takahashi, Eiji; Tanaka, Motoyuki; Matsunaga, Yoko; Okada, Yutaka; Matsumoto, Ryoji; Nambu, Fumio; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5361 - 5371
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in toluene
T=100°C; 3 h; Inert atmosphere;
参考文献
CROWN BIOSCIENCE INC. (TAICANG); ZHANG, Deyi; ZHANG, Ruihao; ZHONG, Boyu; SHIH, Chuan
Patent: WO2014/418 A1, 2014 ;
Location in patent: Page/Page column 92 ;
