1,1,3,3,3-五氟-2-三氟甲基丙基甲基醚合成路线 （共 17 条）
反应条件
1: 1.) triethylamine, 2.) conc. H2SO4 / 1.) DMF, from 10 to 20 deg C, 2.) ether, RT, overnight
2: 60 percent / CsF / bis-(2-methoxy-ethyl) ether / Ambient temperature
View Scheme
参考文献
Ishikawa, Nobuo; Yokozawa, Tsutomu
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 3 p. 724 - 726
反应条件
1: 1.) triethylamine, 2.) conc. H2SO4 / 1.) DMF, from 10 to 20 deg C, 2.) ether, RT, overnight
2: 45 percent / CsF / bis-(2-methoxy-ethyl) ether / 0.83 h / 70 - 75 °C
View Scheme
参考文献
Ishikawa, Nobuo; Yokozawa, Tsutomu
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 3 p. 724 - 726
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
T=0°C; 0.5 h;
参考文献
Inouye,Y.; Higuchi,Y.
Journal of Fluorine Chemistry, 1985 , vol. 27, p. 231
反应条件
1: 72 percent / CaOH, benzyltriethylammonium chloride / H2O
2: 98 percent / aq. sodium hydroxide / CH2Cl2 / 0.5 h / Ambient temperature
View Scheme
参考文献
Inouye,Y.; Higuchi,Y.
Journal of Fluorine Chemistry, 1985 , vol. 27, p. 231
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
T=0°C; 0.5 h; different conditions; Product distribution;
参考文献
Inouye,Y.; Higuchi,Y.
Journal of Fluorine Chemistry, 1985 , vol. 27, p. 231
反应条件
1: 77.7 percent / NaOH / 1.8 h / 65 - 85 °C
2: hydrogen
View Scheme
参考文献
Misaki, Susumu
Journal of Fluorine Chemistry, 1985 , vol. 29, p. 471 - 475
反应条件
SbF5 in neat (no solvent)
参考文献
England, David C.
Journal of Organic Chemistry, 1984 , vol. 49, # 21 p. 4007 - 4008
