2-(2-吡啶基)苯并噻吩合成路线 （共 15 条）
反应条件
PdCl2(PPh3)2; potassium carbonate in ethylene glycol dimethyl ether; water T=80°C; 14 h;
参考文献
Pospech, Jola; Tlili, Anis; Spannenberg, Anke; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2014 , vol. 20, # 11 p. 3135 - 3141
反应条件
1: benzo[b]thiophene With n-butyllithium in tetrahydrofuran T=-75°C; 1 h; Inert atmosphere; 2: With zinc(II) chloride−TMEDA in tetrahydrofuran T=-75 - 20°C; 3: alpha-chloropyridine Further stages;
参考文献
Seggio, Anne; Priem, Ghislaine; Chevallier, Floris; Mongin, Florence
Synthesis, 2009 , # 21 p. 3617 - 3632
反应条件
copper diacetate; potassium ethylxanthate; (R)-(+)-1,1'-binaphthyl-2,2'-diamine in N,N-dimethyl-formamide T=80°C; 35 h; Inert atmosphere;
参考文献
Prasad; Sekar
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 10 p. 1659 - 1665
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethanol T=100°C; Suzuki Coupling; 18 h; Inert atmosphere;
参考文献
Goggins, Sean; Rosevere, Eleanor; Bellini, Clement; Allen, Joseph C.; Marsh, Barrie J.; Mahon, Mary F.; Frost, Christopher G.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 1 p. 47 - 52
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethanol T=100°C; Suzuki Coupling; 18 h; Inert atmosphere;
参考文献
Goggins, Sean; Rosevere, Eleanor; Bellini, Clement; Allen, Joseph C.; Marsh, Barrie J.; Mahon, Mary F.; Frost, Christopher G.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 1 p. 47 - 52
反应条件
in ethanol; nitrogen; toluene
参考文献
CANON KABUSHIKI KAISHA
Patent: EP1211257 A2, 2002 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in ethanol T=100°C; Suzuki Coupling; 18 h; Inert atmosphere;
参考文献
Goggins, Sean; Rosevere, Eleanor; Bellini, Clement; Allen, Joseph C.; Marsh, Barrie J.; Mahon, Mary F.; Frost, Christopher G.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 1 p. 47 - 52
反应条件
C42H44Cl3N3Pd in tetrahydrofuran; 1,4-dioxane T=0 - 80°C; Negishi Coupling; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Liu, Zelong; Dong, Ningning; Xu, Mizhi; Sun, Zheming; Tu, Tao
Journal of Organic Chemistry, 2013 , vol. 78, # 15 p. 7436 - 7444
反应条件
1: 2-hydroxy-pyridine With potassium carbonate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane T=100°C; 3 h; Inert atmosphere; 2: benzo[B]thiophene-2-boronic acid With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane; water T=100°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Li, Shui-Ming; Huang, Jie; Chen, Guo-Jun; Han, Fu-She
Chemical Communications, 2011 , vol. 47, # 48 p. 12840 - 12842
反应条件
palladium diacetate; potassium carbonate; tri-cyclo-hexyl-phosphine; 2,2,2-trimethylacetic acid in N,N-dimethyl-formamide T=180°C; 1 h; Inert atmosphereMicrowave irradiation;
参考文献
Baghbanzadeh, Mostafa; Pilger, Christian; Oliver Kappe
Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 8138 - 8142
