1-(4-甲氧基苯基)哌嗪合成路线 （共 36 条）
反应条件
1: in butan-1-ol 0.1 h; Microwave irradiation; 2: With sodium carbonate in butan-1-ol 0.316667 h; CoolingMicrowave irradiation;
参考文献
Huazhong University of Science and Technology; Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.; JIANG, Fengchao; ZHOU, Ping; CHEN, Jianguo; WANG, Yue; CAO, Baoshuai; YAN, Jia
Patent: EP2682390 A1, 2014 ;
Location in patent: Paragraph 0081 ;
反应条件
(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran; toluene T=80 - 90°C; 24 h;
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh; Shen, Lan; Anderson Evans; Goodman, Andrew
Tetrahedron Letters, 2002 , vol. 43, # 18 p. 3359 - 3363
反应条件
sodium carbonate in butan-1-ol 0.416667 h; Microwave irradiation;
参考文献
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.; Huazhong University of Science and Technology; JIANG, Fengchao; ZHOU, Ping; CHEN, Jianguo; WANG, Yue; CAO, Baoshuai; YAN, Jia
Patent: US2014/4155 A1, 2014 ;
Location in patent: Paragraph 0091 ;
反应条件
1: piperazine With [2,2']bipyridinyl; 1,1-dimethylpropan-1-ol; nickel diacetate in tetrahydrofuran T=63°C; complex formation; 2 h; 2: 1-methoxy-4-chlorobenzene With styrene in tetrahydrofuran Arylation; 8 h; Heating;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924
反应条件
1: piperazine With [2,2']bipyridinyl; 1,1-dimethylpropan-1-ol; nickel diacetate in tetrahydrofuran T=63°C; complex formation; 2 h; 2: 1-methoxy-4-chlorobenzene With styrene in tetrahydrofuran Arylation; 12 h; Heating;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924
反应条件
sodium t-butanolate; [Pd2(dba)2]; tri-tert-butyl phosphine in o-xylene T=120°C; Yield given. Yields of byproduct given;
参考文献
Nishiyama, Masakazu; Yamamoto, Toshihide; Koie, Yasuyuki
Tetrahedron Letters, 1998 , vol. 39, # 7 p. 617 - 620
反应条件
potassium phosphate; copper(l) iodide in isopropyl alcohol T=20°C;
参考文献
Sun, Qi; Yue, Cai-Qin; Ye, Jia; Li, Chang-Ling; Cheng, Tie-Ming; Li, Run-Tao
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6245 - 6249
反应条件
1.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium(0); 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / toluene / 100 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 2.2: pH 7 - 8 View Scheme
参考文献
BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
WO 2011/028947 A1
反应条件
hydrogen bromide 1.) glacial HOAc, RT, 96 h, 2.) MeOH, reflux, 96 h; Yield given. Multistep reaction;
参考文献
Poindexter, Graham S.; Bruce, Marc A.; LeBoulluec, Karen L.; Monkovic, Ivo
Tetrahedron Letters, 1994 , vol. 35, # 40 p. 7331 - 7334
反应条件
1.) DMSO, 25 deg C, 3.5 h, in dark, 2.) DMSO, 80 deg C, 4 h, hν; Yield given. Multistep reaction;
参考文献
Perez, Michel; Potier, Pierre; Halazy, Serge
Tetrahedron Letters, 1996 , vol. 37, # 47 p. 8487 - 8488
