1-(4-甲氧基苯基)哌嗪合成路线 （共 36 条）
反应条件
hydrogen bromide Heatingovernight;
参考文献
Stefancich; Artico; Ortar; Silvestri; Simonetti; Apuzzo
Archiv der Pharmazie, 1992 , vol. 325, # 11 p. 687 - 694
反应条件
1: 94 percent / 1.) 55 deg C, 2 h, 2.) RT, overnight 2: 64 percent / LiAlH4 / diethyl ether / 9 h / Heating View Scheme
参考文献
UNIVERSITY OF KANSAS; THE SCRIPPS RESEARCH INSTITUTE; AUBE, Jeffrey; BOHN, Laura; PRISINZANO, Thomas, Edward; SCHOENEN, Frank, John; FRANKOWSKI, Kevin, John
Patent: WO2013/40321 A1, 2013 ;
反应条件
1: Et3N / acetonitrile / 100 °C 2: hydrazine hydrate / ethanol / 80 °C View Scheme
参考文献
Guo, Dong; Xia, Lizi; Van Veldhoven, Jacobus P. D.; Hazeu, Marc; Mocking, Tamara; Brussee, Johannes; Ijzerman, Adriaan P.; Heitman, Laura H.
ChemMedChem, 2014 , vol. 9, # 4 p. 752 - 761
反应条件
in toluene Alkylation; 6 h; Heating;
参考文献
Caliendo, Giuseppe; Fiorino, Ferdinando; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Severino, Beatrice; Bruni, Giancarlo; Romeo, Maria Rosaria
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 533 - 538
反应条件
1: 67 percent / K2CO3 / dimethylsulfoxide / 120 °C 2: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 3: 61 percent / pyridine / CHCl3 / 3 h 4: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating 5: 28 percent / NaOAc / butan-1-ol 6: 57 percent / KOH / dimethylsulfoxide / 14 h 7: 38 percent / 48percent aq. HBr / Heating View Scheme
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900
反应条件
1: 67 percent / K2CO3 / dimethylsulfoxide / 120 °C 2: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 3: 61 percent / pyridine / CHCl3 / 3 h 4: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating 5: 28 percent / NaOAc / butan-1-ol View Scheme
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900
反应条件
1: 77 percent / potassium carbonate; tetra-N-butylammonium iodide / dimethylsulfoxide / Heating 2: H2 / Pd/C 3: HBr / Heating View Scheme
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh
Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5655 - 5659
反应条件
1: 67 percent / K2CO3 / dimethylsulfoxide / 120 °C 2: 74 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating View Scheme
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh
Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5655 - 5659
反应条件
1: 100 percent / 48 percent HBr / Heating; overnight 2: 100 percent / sodium acetate / acetic acid / 0.75 h / Heating 3: 92 percent / KHCO3, H2O / methanol / Ambient temperature View Scheme
参考文献
Stefancich; Artico; Ortar; Silvestri; Simonetti; Apuzzo
Archiv der Pharmazie, 1992 , vol. 325, # 11 p. 687 - 694
反应条件
hydrogen bromide T=140°C; 6 h;
参考文献
Komoto; Okada; Sato; Niino; Oka; Sakamoto
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 10 p. 1314 - 1320
