1-(4-甲氧基苯基)哌嗪合成路线 （共 36 条）
反应条件
1: 53 percent / H2O / 0.5 h / 50 - 60 °C
2: 48 percent / 50 percent aq. NaOH, triethylamine / CHCl3 / 40 - 50 °C
View Scheme
参考文献
Schroth, W.; Kluge, H.; Frach, R.; Hodek, W.; Schaedler, H. D.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 5 p. 787 - 802
反应条件
1: 60 percent / 25percent KOH / acetone / 8 h
2: NaOH / ethanol; H2O / Heating
View Scheme
参考文献
Agarwal, Shiv K.; Kumar, Yatendra; Saxena, Anil K.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 435 - 439
反应条件
1: 60 percent / 25percent KOH / acetone / 8 h
2: NaOH / ethanol; H2O / Heating
View Scheme
参考文献
Agarwal, Shiv K.; Kumar, Yatendra; Saxena, Anil K.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 435 - 439
反应条件
triethylamine in dichloromethane
T=0°C; 0.5 h;
参考文献
Steinhagen, Henning; Gerisch, Michael; Mittendorf, Joachim; Schlemmer, Karl-Heinz; Albrecht, Barbara
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3187 - 3190
反应条件
sodium hydrogencarbonate in dichloromethane; water
2 h; Ambient temperature;
参考文献
Mes, Ger F.; Ramesdonk, Hendrik J. van; Verhoeven, Jan W.
Journal of the American Chemical Society, 1984 , vol. 106, # 5 p. 1335 - 1340
参考文献
SmithKline Corporation
Patent: US3988457 A1, 1976 ;
