2-乙酰基-5-溴苯并[b]呋喃合成路线 （共 16 条）
反应条件
1: 70 percent / N-methylpyrrolidine / 0.5 h / Heating
2: 96 percent / aqu NaOH, Br2 / dioxane / 50 - 60 °C
3: 81 percent / SOCl2 / dimethylformamide / 0.75 h / Heating
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 70 percent / N-methylpyrrolidine / 0.5 h / Heating
2: 96 percent / aqu NaOH, Br2 / dioxane / 50 - 60 °C
3: 1) SOCl2 / 1) DMF, 45 min, reflux; 2) benzene, 2 min, reflux
4: 1) HCl (g); 2) NH3 (g) / 1) chloroform, ethanol, 7 d; 2) ether, ethanol, 7 d
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: 70 percent / N-methylpyrrolidine / 0.5 h / Heating
2: 96 percent / aqu NaOH, Br2 / dioxane / 50 - 60 °C
3: 1) SOCl2 / 1) DMF, 45 min, reflux; 2) benzene, 2 min, reflux
View Scheme
参考文献
Dann, Otto; Char, Helmut; Griessmeier, Helmut
Liebigs Annalen der Chemie, 1982 , # 10 p. 1836 - 1869
反应条件
1: Br2
2: [18]-crown-6
View Scheme
参考文献
Paizs, Csaba; Tosa, Monica; Majdik, Cornelia; Moldovan, Paula; Novak, Lajos; Kolonits, Pal; Marcovici, Adriana; Irimie, Florin-Dan; Poppe, Laszlo
Tetrahedron Asymmetry, 2003 , vol. 14, # 11 p. 1495 - 1501
反应条件
1: (i) H2SO4, EtOH, (heating), (ii) PPA, (heating)
3: nitrobenzene / 336 h
View Scheme
参考文献
Dann,O. et al.
Justus Liebigs Annalen der Chemie, 1973 , p. 1112 - 1140
反应条件
1: (i) MeOH, (heating), (ii) PPA, (heating)
2: 0.75 h
3: nitrobenzene / 336 h
View Scheme
参考文献
Dann,O. et al.
Justus Liebigs Annalen der Chemie, 1973 , p. 1112 - 1140
