N-isopropylcarbamoyl-derivatized cyclofructan-6 column in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Resolution of racemate;

1: 2) 10percent NaOH / methanol; diethyl ether / 24 h / Ambient temperature 2: 0 °C 3: 1) 2M Na/BuOH, 2) 48percent HBr / 1) reflux, 2 h, 2) reflux, 6 h View Scheme

hydrogen bromide; sodium; butan-1-ol 1) reflux, 2 h, 2) reflux, 6 h; Yield given;