5-溴-4-硝基噻吩-2-羧酸甲酯合成路线 (共 11 条)
反应条件
sulfuric acid; nitric acid
参考文献
Kiryanov, Andre A.; Seed, Alexander J.; Sampson, Paul
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8797 - 8800
反应条件
1: 95 percent / H2SO4 2: 60 percent / HNO3; H2SO4 View Scheme
参考文献
Kiryanov, Andre A.; Seed, Alexander J.; Sampson, Paul
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8797 - 8800
反应条件
1.1: 94 percent / Zn; HCl / ethanol 2.1: NaNO2; HCl; HPF6 2.2: 180 - 200 °C 3.1: 100 percent / Br2 / CHCl3 / 2.5 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 50 p. 8797 - 8800
反应条件
hydrogenchloride; zinc in ethanol
参考文献
Kiryanov, Andre A.; Seed, Alexander J.; Sampson, Paul
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8797 - 8800
反应条件
1.1: 94 percent / Zn; HCl / ethanol 2.1: NaNO2; HCl; HPF6 2.2: 180 - 200 °C View Scheme
参考文献
Kiryanov, Andre A.; Seed, Alexander J.; Sampson, Paul
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8797 - 8800
反应条件
1: in DMF (N,N-dimethyl-formamide)
T=80°C; 3 h;
2: With hydrogenchloride; anhydrous iron chloride in DMF (N,N-dimethyl-formamide); water
T=60°C; 0.333333 h;
参考文献
PHARMACIA ITALIA S.P.A.
Patent: WO2004/7504 A1, 2004 ;
Location in patent: Page 37 ;
WO 2004/007504 A1
反应条件
1: in N,N-dimethyl-formamide
T=80°C; 3 h;
2: With hydrogenchloride; anhydrous iron chloride in water; N,N-dimethyl-formamide
T=60°C; 0.333333 h;
参考文献
Pharmacia Italia S.p.A.
Patent: US2006/160874 A1, 2006 ;
Location in patent: Page/Page column 14 ;
US 20060160874 A1
参考文献
Motoyama et al.
Nippon Kagaku Zasshi, 1957 , vol. 78, p. 779,783
Chem.Abstr., 1960 , p. 22559
Full Text Show Details
Nishimura et al.
Bl. Univ. Osaka Prefect., 1958 , vol. <A> 6, p. 127,130
反应条件
iron in acetic acid
T=75 - 80°C;
参考文献
Gol'dfarb, Ya. L.; Bulgakova, V. N.; Fabrichnyi, B. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1283 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1626 - 1629
反应条件
hydrogenchloride; tin
Behandeln des Reaktionsprodukts mit Acetanhydrid;
参考文献
Motoyama et al.
Nippon Kagaku Zasshi, 1957 , vol. 78, p. 779,783
Chem.Abstr., 1960 , p. 22559