5-溴-3-甲基噻吩-2-甲酸合成路线 （共 3 条）
反应条件
bromine in water; acetic acid T=10 - 15°C; 2 h;
参考文献
AGOURON PHARMACEUTICALS, INC.
Patent: US2004/266796 A1, 2004 ;
Location in patent: Page 13 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 1 h; 2: With bromine in tetrahydrofuran; hexanes T=-78 - 20°C; 2 h;
参考文献
NOVARTIS AG; XENON PHARMACEUTICALS INC.
Patent: WO2008/74835 A1, 2008 ;
Location in patent: Page/Page column 78 ;
WO 2008/074835 A1
反应条件
1: With sodium chlorate; sodium dihydrogenphosphate; dihydrogen peroxide in water; acetonitrile T=0 - 20°C; 3.5 h; 2: With sodium sulfite in water; acetonitrile T=20°C; 0.25 h; 3: With hydrogenchloride in water; acetonitrile pH=3;
参考文献
FibroGen, Inc.
Patent: US2006/199836 A1, 2006 ;
Location in patent: Page/Page column 22 ;
US 20060199836 A1
