5-溴-3-甲基噻吩-2-甲醛合成路线 (共 2 条)
反应条件
1: With sodium chlorate; sodium dihydrogenphosphate; dihydrogen peroxide in water; acetonitrile T=0 - 20°C; 3.5 h; 2: With sodium sulfite in water; acetonitrile T=20°C; 0.25 h; 3: With hydrogenchloride in water; acetonitrile pH=3;
参考文献
FibroGen, Inc.
Patent: US2006/199836 A1, 2006 ;
Location in patent: Page/Page column 22 ;
US 20060199836 A1
反应条件
bromine in chloroform
T=0 - 20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHAO, Guohua; WASHBURN, William N.; MIGNONE, James
Patent: WO2010/42674 A1, 2010 ;
Location in patent: Page/Page column 55; 56 ;
WO 2010/042674 A1