(E)-2-氧代戊烯二酸二甲酯合成路线 （共 8 条）
反应条件
1: 11 percent / toluenesulfonic acid / CH2Cl2 / 24 h / Heating 2: 79 percent / aq. OH- / tetrahydrofuran View Scheme
参考文献
Carrigan, Christina N.; Esslinger, C. Sean; Bartlett, Richard D.; Bridges, Richard J.; Thompson, Charles M.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2607 - 2612
反应条件
1: 2.) HCl / 1.) CH2Cl2, room temp., 12 h; 2.) 12 h, ether 2: 1.) BBr3; 2.) MeOH, H2SO4 (96percent) / 1.) CH2Cl2, room temp., 140 h; 2.) reflux, 48 h 3: 93 percent / benzoyl t-butyl nitroxide / methanol; CHCl3 / 16 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 42, # 12 p. 3259 - 3268
反应条件
1: 16 percent / toluenesulfonic acid / CH2Cl2 / 24 h / Heating 2: 81 percent / aq. OH- / tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 11 p. 2260 - 2276
反应条件
acid in dichloromethane Cyclization; Michael addition; dehydration; aromatization;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 17 p. 2607 - 2612
反应条件
toluene-2-sulfonic acid in dichloromethane
24 h; Heating;
参考文献
Carrigan, Christina N.; Bartlett, Richard D.; Esslinger, C. Sean; Cybulski, Kimberly A.; Tongcharoensirikul, Pakamas; Bridges, Richard J.; Thompson, Charles M.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2260 - 2276
反应条件
1: 2.) HCl / 1.) CH2Cl2, room temp., 12 h; 2.) 12 h, ether
2: 1.) BBr3; 2.) MeOH, H2SO4 (96percent) / 1.) CH2Cl2, room temp., 140 h; 2.) reflux, 48 h
3: 93 percent / benzoyl t-butyl nitroxide / methanol; CHCl3 / 16 h / Ambient temperature
View Scheme
参考文献
MacKenzie, A. Roderick; Moody, Christopher J.; Rees, Charles W.
Tetrahedron, 1986 , vol. 42, # 12 p. 3259 - 3268
反应条件
toluene-4-sulfonic acid in toluene
4 h; Heating;
参考文献
Clavier, Sylvain; Rist, ystein; Hansen, Stina; Gerlach, Lars-Ole; Hoegberg, Thomas; Bergman, Jan
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 23 p. 4248 - 4253
反应条件
1: 40 percent / toluenesulfonic acid / CH2Cl2 / 24 h / Heating
2: 43 percent / aq. OH- / tetrahydrofuran
View Scheme
参考文献
Carrigan, Christina N.; Esslinger, C. Sean; Bartlett, Richard D.; Bridges, Richard J.; Thompson, Charles M.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2607 - 2612
