苯基 5-乙酰基-4-甲基-1,3-噻唑-2-基氨基甲酸酯合成路线 （共 3 条）
反应条件
1: 2-amino-5-acetyl-4-methyl-thiazole With sodium hydride in N,N-dimethyl-formamide
T=0°C;
2: carbonic acid diphenyl ester T=20°C; 0.5 h;
参考文献
Batt, Douglas G.
Patent: US2004/67935 A1, 2004 ;
Location in patent: Page/Page column 31 ;
US 20040067935 A1
反应条件
1: 2-amino-5-acetyl-4-methyl-thiazole With sodium hydride in DMF (N,N-dimethyl-formamide)
T=0°C;
2: carbonic acid diphenyl ester in DMF (N,N-dimethyl-formamide)
T=0 - 20°C;
参考文献
Ko, Soo S.; Delucca, George V.
Patent: US2004/259914 A1, 2004 ;
Location in patent: Page 20 ;
US 20040259914 A1
反应条件
1: With pyridine
T=0 - 20°C; 0.166667 h;
2: With sodium hydrogencarbonate in water
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/48771 A1, 2007 ;
Location in patent: Page/Page column 50 ;
WO 2007/048771 A1
