2-巯甲基嘧啶-5-羧酸甲酯合成路线 （共 6 条）
反应条件
in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
MIKANA THERAPEUTICS, INC.
Patent: WO2006/88949 A1, 2006 ;
Location in patent: Page/Page column 91 ;
反应条件
in methanol T=2°C; Substitution; Heating;
参考文献
Tumkevicius; Yakubkene; Vainilavicius
Chemistry of Heterocyclic Compounds, 1999 , vol. 35, # 11 p. 1334 - 1336
反应条件
in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
Zhichkin, Pavel; Fairfax, David J.; Eisenbeis, Shane A.
Synthesis, 2002 , # 6 p. 720 - 722
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; toluene T=-78°C; 2.66667 h; 2: With acetic acid in tetrahydrofuran; toluene T=-78°C;
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; SCHLEGEL, Kelly-Ann; YANG, Zhi-Qiang
Patent: WO2011/84368 A1, 2011 ;
Location in patent: Page/Page column 58-59 ;
WO 2011/084368 A1
反应条件
1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2.67 h / -78 °C 1.2: -78 °C 2.1: thionyl bromide / dichloromethane / 2.5 h / 20 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; SCHLEGEL, Kelly-Ann; YANG, Zhi-Qiang
Patent: WO2011/84368 A1, 2011 ;
WO 2011/084368 A1
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=20°C;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2007/41634 A1, 2007 ;
Location in patent: Page/Page column 67 ;
WO 2007/041634 A1
