2-氰基-5-氟嘧啶合成路线

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED; CHUAQUI, Claudio, Edmundo; HUANG, Shan; IOANNIDIS, Stephanos; SHI, Jie; SU, Mei; SU, Qibin
Patent: WO2010/38060 A1, 2010 ;
Location in patent: Page/Page column 64-65 ;
WO 2010/038060 A1

75-86-5丙酮氰醇+

62802-42-02-氯-5-氟嘧啶

38275-55-72-氰基-5-氟嘧啶

参考文献

Frodsham, Lianne; Golden, Michael; Hard, Susan; Kenworthy, Martin N.; Klauber, David J.; Leslie, Kevin; Macleod, Claire; Meadows, Rebecca E.; Mulholland, Keith R.; Reilly, Julie; Squire, Christopher; Tomasi, Simone; Watt, Denise; Wells, Andrew S.
Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1123 - 1130

947533-45-12-溴-5-氟嘧啶+

75-86-5丙酮氰醇

38275-55-72-氰基-5-氟嘧啶

参考文献

Frodsham, Lianne; Golden, Michael; Hard, Susan; Kenworthy, Martin N.; Klauber, David J.; Leslie, Kevin; Macleod, Claire; Meadows, Rebecca E.; Mulholland, Keith R.; Reilly, Julie; Squire, Christopher; Tomasi, Simone; Watt, Denise; Wells, Andrew S.
Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1123 - 1130

38275-55-72-氰基-5-氟嘧啶

参考文献

Ioannidis, Stephanos; Lamb, Michelle L.; Davies, Audrey M.; Almeida, Lynsie; Su, Mei; Bebernitz, Geraldine; Ye, Minwei; Bell, Kirsten; Alimzhanov, Marat; Zinda, Michael
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6524 - 6528

75-16-1甲基溴化镁+

108-24-7乙酸酐+

38275-55-72-氰基-5-氟嘧啶

905587-32-8N-[1-(5-氟-嘧啶-2-基)乙烯基]-乙酰胺

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/135785 A1, 2008 ;
Location in patent: Page/Page column 55 ;
WO 2008/135785 A1

108-24-7乙酸酐+

38275-55-72-氰基-5-氟嘧啶

905587-32-8N-[1-(5-氟-嘧啶-2-基)乙烯基]-乙酰胺

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/129255 A1, 2008 ;
Location in patent: Page/Page column 71 ;
WO 2008/129255 A1

38275-55-72-氰基-5-氟嘧啶

905587-41-91-(5-氟嘧啶-2-基)乙胺

参考文献

Ioannidis, Stephanos; Lamb, Michelle L.; Wang, Tao; Almeida, Lynsie; Block, Michael H.; Davies, Audrey M.; Peng, Bo; Su, Mei; Zhang, Hai-Jun; Hoffmann, Ethan; Rivard, Caroline; Green, Isabelle; Howard, Tina; Pollard, Hannah; Read, Jon; Alimzhanov, Marat; Bebernitz, Geraldine; Bell, Kirsten; Ye, Minwei; Huszar, Dennis; Zinda, Michael
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 262 - 276

38275-55-72-氰基-5-氟嘧啶

905587-43-11-(5-氟嘧啶-2-基)乙醇

参考文献

Ioannidis, Stephanos; Lamb, Michelle L.; Wang, Tao; Almeida, Lynsie; Block, Michael H.; Davies, Audrey M.; Peng, Bo; Su, Mei; Zhang, Hai-Jun; Hoffmann, Ethan; Rivard, Caroline; Green, Isabelle; Howard, Tina; Pollard, Hannah; Read, Jon; Alimzhanov, Marat; Bebernitz, Geraldine; Bell, Kirsten; Ye, Minwei; Huszar, Dennis; Zinda, Michael
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 262 - 276

75-16-1甲基溴化镁+

38275-55-72-氰基-5-氟嘧啶

905587-44-21-(5-氟嘧啶-2-基)乙酮

参考文献

Ioannidis, Stephanos; Lamb, Michelle L.; Wang, Tao; Almeida, Lynsie; Block, Michael H.; Davies, Audrey M.; Peng, Bo; Su, Mei; Zhang, Hai-Jun; Hoffmann, Ethan; Rivard, Caroline; Green, Isabelle; Howard, Tina; Pollard, Hannah; Read, Jon; Alimzhanov, Marat; Bebernitz, Geraldine; Bell, Kirsten; Ye, Minwei; Huszar, Dennis; Zinda, Michael
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 262 - 276

676-58-4甲基氯化镁+

38275-55-72-氰基-5-氟嘧啶

905587-44-21-(5-氟嘧啶-2-基)乙酮

参考文献

Frodsham, Lianne; Golden, Michael; Hard, Susan; Kenworthy, Martin N.; Klauber, David J.; Leslie, Kevin; Macleod, Claire; Meadows, Rebecca E.; Mulholland, Keith R.; Reilly, Julie; Squire, Christopher; Tomasi, Simone; Watt, Denise; Wells, Andrew S.
Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1123 - 1130