1: With diisobutylaluminium hydride in tetrahydrofuran T=-78°C; 2.33333 h; 2: With hydrogenchloride; water in tetrahydrofuran; methanol T=18 - 25°C; 2 h;

1.1: tetrahydrofuran; 2-methyl tetrahydrofuran / -40 °C 1.2: -25 °C 2.1: (S)-1-phenyl-ethylamine; potassium dihydrogenphosphate; pyridoxal 5'-phosphate; potassium carbonate; acetic acid; ω-transaminase / water; toluene / 18 h / 29 °C / pH 7.5 / |Enzymatic reaction 3.1: potassium carbonate / 2-methyl tetrahydrofuran; water / 18 h / 40 °C 4.1: hydrogenchloride / isopropyl alcohol / 24 h / 40 °C View Scheme