2-(4-溴苯基)-吡咯烷合成路线 （共 5 条）
反应条件
sodium tetrahydroborate; water in methanol T=-41 - 20°C;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 196 ;
反应条件
1: triphenylphosphine / hexane / 14 h / 20 °C 2: NaBH4; acetic acid / methanol / -45 °C View Scheme
参考文献
Rogers, Claude J.; Dickerson, Tobin J.; Brogan, Andrew P.; Janda, Kim D.
Journal of Organic Chemistry, 2005 , vol. 70, # 9 p. 3705 - 3708
反应条件
1: NaN3; NaI / dimethylsulfoxide / 15 h / 55 °C 2: triphenylphosphine / hexane / 14 h / 20 °C 3: NaBH4; acetic acid / methanol / -45 °C View Scheme
参考文献
Rogers, Claude J.; Dickerson, Tobin J.; Brogan, Andrew P.; Janda, Kim D.
Journal of Organic Chemistry, 2005 , vol. 70, # 9 p. 3705 - 3708
反应条件
1.1: trifluoroacetic acid / 6 h 1.2: pH 13 - 14 2.1: sodium tetrahydroborate / water; methanol / 4 h / -41 - 20 °C View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
反应条件
triethylamine in tetrahydrofuran
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US6548494 B1, 2003 ;
