(Z)-7-[(1r,2r,3r,5s)-3,5-二羟基-2-((e)-(s)-3-羟基-5-苯基-1-戊烯)-环戊基]-5-庚烯酸甲酯合成路线 (共 5 条)
反应条件
caesium carbonate in N,N-dimethyl-formamide T=0 - 4°C; 4 h;
参考文献
Gutman, Arie; Rukhman, Igor; Tishin, Boris; Yudovich, Lev; Vilensky, Alexander; Pertsikov, Boris; Nisnevich, Gennady
Patent: US2009/163596 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
1: With 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride in toluene T=-70 - 20°C; 2: With hydrogenchloride in water; toluene
参考文献
YONSUNG FINE CHEMICAL CO., LTD.; OH, Changyoung; LEE, Kee Young; KIM, Yong Hyun; JOO, Jae Eun
Patent: WO2010/104344 A2, 2010 ;
Location in patent: Paragraph 102-104 ;
反应条件
pyridinium p-toluenesulfonate in methanol T=20 - 40°C;
参考文献
JOHNSON MATTHEY PUBLIC LIMITED COMPANY
Patent: WO2005/58812 A2, 2005 ;
Location in patent: Page/Page column 46 ;
反应条件
in diethyl ether Esterification;
参考文献
Wang, Yili; Wos, John A.; Dirr, Michelle J.; Soper, David L.; DeLong, Mitchell A.; Mieling, Glen E.; De, Biswanath; Amburgey, Jack S.; Suchanek, Eric G.; Taylor, Cynthia J.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 945 - 952
反应条件
in methanol T=24 - 27°C; 72 h; Product distribution / selectivity;
参考文献
Gutman, Arie; Rukhman, Igor; Tishin, Boris; Yudovich, Lev; Vilensky, Alexander; Pertsikov, Boris; Nisnevich, Gennady
Patent: US2009/163596 A1, 2009 ;
Location in patent: Page/Page column 18 ;