2-羟基-4-氨基-5-氯-N,N-二乙基氨基乙基苯甲酰胺合成路线 （共 6 条）
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide 16 h; Ambient temperature;
参考文献
Monkovic, Ivo; Wllner, David; Adam, Michael A.; Brown, Myron; Crenshaw, R. R.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1548 - 1557
反应条件
pyridine; sodium hydroxide in water
参考文献
MARION MERRELL DOW INC.
Patent: EP431561 A2, 1991 ;
反应条件
sodium hydride; ethanethiol in N,N-dimethyl-formamide
T=100 - 105°C; 1.5 h;
参考文献
Monkovic, Ivo; Wllner, David; Adam, Michael A.; Brown, Myron; Crenshaw, R. R.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1548 - 1557
反应条件
hydrogenchloride; sodium hydroxide; ammonia in methanol; dichloromethane; water
参考文献
Bristol-Myers Company
Patent: US4808624 A1, 1989 ;
US 4808624 A
反应条件
pH = 8 in water
T=56°C; var. pH (from 8 to 10); Rate constant;
参考文献
Nassar; House; Agharkar
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 11 p. 1088 - 1091
反应条件
pH = 6 in water
T=56°C; var. pH (from 6 to 8); Rate constant;
参考文献
Nassar; House; Agharkar
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 11 p. 1088 - 1091
