2-硝基-Alpha,Alpha,Alpha-三氟甲苯合成路线 （共 51 条）
反应条件
ammonia; sodium amide
参考文献
Kobayashi; Kumadaki; Hanzawa; Mimura
Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 3 p. 636 - 639
反应条件
1: Raney nickel; dioxane / 180 °C / 14710.2 Torr / Hydrogenation 2: aqueous HCl; sodium acetate; H2O / Diazotization View Scheme
参考文献
Pettit; Tatlow
Journal of the Chemical Society, 1954 , p. 1071,1073
反应条件
tetrabutylammomium bromide; sodium hydride in N,N-dimethyl-formamide
T=110°C; Inert atmosphereSchlenk technique;
参考文献
Liu, Zhenxing; Wang, Long; Tan, Haocheng; Zhou, Shiyi; Fu, Tianren; Xia, Ying; Zhang, Yan; Wang, Jianbo
Chemical Communications, 2014 , vol. 50, # 39 p. 5061 - 5063
反应条件
potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide
T=-40°C; 0.00416667 h; Inert atmosphere;
参考文献
Blazej, Sylwia; Makosza, Mieczyslaw
Chemistry - A European Journal, 2008 , vol. 14, # 35 p. 11113 - 11122
反应条件
potassium hydroxide in dimethyl sulfoxide
1 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Makosza, M.; Glinka, T.; Kinowski, A.
Tetrahedron, 1984 , vol. 40, # 10 p. 1863 - 1868
反应条件
potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide
T=-40°C; 0.00416667 h; Inert atmosphere;
参考文献
Blazej, Sylwia; Makosza, Mieczyslaw
Chemistry - A European Journal, 2008 , vol. 14, # 35 p. 11113 - 11122
反应条件
potassium tert-butylate; acetic acid in tetrahydrofuran
T=-50 - 20°C; 0.5 h;
参考文献
Makosza, M.; Glinka, T.; Kinowski, A.
Tetrahedron, 1984 , vol. 40, # 10 p. 1863 - 1868
反应条件
potassium hydroxide in dimethyl sulfoxide
1 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Makosza, M.; Glinka, T.; Kinowski, A.
Tetrahedron, 1984 , vol. 40, # 10 p. 1863 - 1868
反应条件
potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide
T=-40°C; 0.00416667 h; Inert atmosphere;
参考文献
Blazej, Sylwia; Makosza, Mieczyslaw
Chemistry - A European Journal, 2008 , vol. 14, # 35 p. 11113 - 11122
反应条件
1: 40 percent / dimethylsulfoxide / 100 - 120 °C
2: 60percent H2SO4 / Heating
View Scheme
参考文献
Gorvin, John H.
Journal of Chemical Research, Miniprint, 1991 , # 4 p. 738 - 762
