3,4,5-三甲氧基苄醇合成路线 （共 102 条）
反应条件
1.1: 83 percent / DMAP; Et3N / tetrahydrofuran / 4 h / 20 °C
2.1: i-PrMgCl*LiCl / tetrahydrofuran; 1,2-dimethoxy-ethane / 4 h / 0 °C
2.2: CuBr; P(OEt)3 / 1,2-dimethoxy-ethane; tetrahydrofuran / 0.17 h / -15 °C
2.3: 81 percent / tetrabutylammonium iodide / tetrahydrofuran; 1,2-dimethoxy-ethane / 1.5 h / 60 °C
3.1: 87 percent / aq. HCl / methanol / 0.25 h / 20 °C
4.1: 86 percent / N,N-dimethylbenzenamine; POCl3 / 1 h / 110 °C
View Scheme
参考文献
Kofink, Christiane C.; Knochel, Paul
Organic Letters, 2006 , vol. 8, # 18 p. 4121 - 4124
反应条件
1: pyridine / benzene / Ambient temperature
2: 15 percent Chromat. / Irradiation
View Scheme
参考文献
Pincock, J. A.; Wedge, P. J.
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5587 - 5595
反应条件
potassium hydroxide; tetrabutylammomium bromide in water; chlorobenzene
T=65°C;
参考文献
Cao, Derong; Dobis, Silvia; Schollmeyer, Dieter; Meier, Herbert
Tetrahedron, 2003 , vol. 59, # 28 p. 5323 - 5327
反应条件
1: aq. HCl
2: N2H4*H2O
View Scheme
参考文献
Kost,A.N. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 6 p. 2011 - 2015,1957 - 1960
反应条件
1: CBr4; triphenylphosphine / acetone / 20 °C
2: 17.64 g / toluene / 2 h / Heating
View Scheme
参考文献
Perez-Melero, Concepcion; Maya, Ana B.S.; Del Rey, Benedicto; Pelaez, Rafael; Caballero, Esther; Medarde, Manuel
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3771 - 3774
参考文献
Nussbaumer, Peter; Winiski, Anthony P.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 16 p. 7552 - 7560
反应条件
1: 3,4,5-trimethoxy-benzyl alcohol With phosphorus tribromide in dichloromethane
T=-5°C; 0.75 h;
2: triphenylphosphine in toluene
T=20°C; 24 h;
参考文献
Falciani, Chiara; Brunetti, Jlenia; Pagliuca, Chiara; Menichetti, Stefano; Vitellozzi, Lucia; Lelli, Barbara; Pini, Alessandro; Bracci, Luisa
ChemMedChem, 2010 , vol. 5, # 4 p. 567 - 574
反应条件
1: pyridinium chlorochromate / CH2Cl2 / 3 h
2: sodium acetate / acetic anhydride / Heating
3: NaOH / H2O / Heating
View Scheme
参考文献
Shaw; Srivastava; Jha
Journal of the Indian Chemical Society, 1990 , vol. 67, # 2 p. 144 - 147
反应条件
iodine; silver trifluoroacetate in dichloromethane
4 h;
参考文献
Larson, Eric R.; Raphael, Ralph A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 521 - 525
反应条件
1: Hg(OAc)2, I2
2: SOCl2, Me2NPh
View Scheme
参考文献
Ziegler,F.E.; Schwatz,J.A.
Journal of Organic Chemistry, 1978 , vol. 43, # 5 p. 985 - 991
