3,4,5-三甲氧基苄醇合成路线 （共 102 条）
反应条件
N-bromosuccinmide in chloroform
3 h; Heating;
参考文献
Ziegler, Frederick E.; Chliwner, Irene; Fowler, Kerry W.; Kanfer, Sheldon J.; Kuo, Stephen J.; Sinha, Nanda D.
Journal of the American Chemical Society, 1980 , vol. 102, # 2 p. 790 - 798
反应条件
1: N.N-dimethyl-aniline; SOCl2 / 0 °C / zuletzt bei 100grad
2: ethanol
View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
反应条件
triethylamine in dichloromethane
1 h;
参考文献
Aventis Pharmaceuticals, Inc.
Patent: US6329392 B1, 2001 ;
US 6329392 B1
反应条件
hydrogenchloride; sodium hydrogencarbonate in acetonitrile
参考文献
Maynard, George D.; Le, Tieu-Binh
Patent: US2001/34343 A1, 2001 ;
反应条件
1: 91 percent / iodine, silver trifluoroacetate
2: 77 percent / Pd(PPh3)4
View Scheme
参考文献
Paleo, M. Rita; Lamas, Carlos; Castedo, Luis; Dominguez, Domingo
Journal of Organic Chemistry, 1992 , vol. 57, # 7 p. 2029 - 2033
反应条件
n-butyllithium
1.) hexane, THF, 20 min, r.t; 2.) hexane, THF, 10 min, r.t.; Yield given. Multistep reaction;
参考文献
Orito, Kazuhiko; Miyazawa, Mamoru; Suginome, Hiroshi
Tetrahedron, 1995 , vol. 51, # 9 p. 2489 - 2496
反应条件
in carbon disulfide
7 h; Heatingin presence of bentonite-clay;
参考文献
Salmon, Manuel; Zavala, Nieves; Martinez, Mariano; Miranda, Rene; Cruz, Raymundo; Cardenas, Jorge; Gavino, Ruben; Cabrera, Armando
Tetrahedron Letters, 1994 , vol. 35, # 32 p. 5797 - 5800
参考文献
Le Baut; Sparfel; Clairc; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 5 p. 441 - 445
反应条件
1.1: PBr3 / CH2Cl2 / 0.75 h / -5 °C
2.1: 73 percent / 2.17 h / 140 - 180 °C
3.1: 93 percent / NaH; 15-crown-5 / tetrahydrofuran
4.1: Na / tetrahydrofuran / 7 h / 20 °C
4.2: 78 percent / H2O / tetrahydrofuran / 0 °C
View Scheme
参考文献
Azzena, Ugo; Dettori, Giovanna; Idini, Maria Vittoria; Pisano, Luisa; Sechi, Grazia
Tetrahedron, 2003 , vol. 59, # 40 p. 7961 - 7966
反应条件
1.1: 79 percent / CF3CO2Ag; I2 / CHCl3 / 1 h / -5 °C
2.1: Jones reagent / acetone; H2O / 0.08 h / 0 °C
2.2: 91 percent / NaH2PO4*2H2O; H2O2; NaClO2 / acetonitrile; H2O / 1 h / 20 °C
View Scheme
参考文献
Takeda, Shigemitsu; Abe, Hitoshi; Takeuchi, Yasuo; Harayama, Takashi
Tetrahedron, 2007 , vol. 63, # 2 p. 396 - 408
