5-(4-甲氧基苯基)噻酚-2-甲醛合成路线 （共 10 条）
反应条件
potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0) in ethanol; toluene Suzuki coupling; 5 h; Heating;
参考文献
Mitsch, Andreas; Altenkaemper, Mirko; Sattler, Isabel; Schlitzer, Martin
Archiv der Pharmazie, 2005 , vol. 338, # 1 p. 9 - 17
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethanol; water; toluene T=60°C; 5 h; Inert atmosphere;
参考文献
ENDO PHARMACEUTICALS INC.; SMITH, Roger, Astbury; LAPING, Nicholas, James; VENKATESAN, Aranapakam; THOMPSON, Scott, Kevin; KETHIRI, Raghava, Reddy; SIVANANDHAN, Dhanalakshmi; VENKATESHAPPA, Chandregowda; KULKARNI, Bheemashankar; DEWANG, Purushottam; KRISTAM, Rajendra; KASIBHATLA, Srinivas; DEVRAJ, Rajesh
Patent: WO2013/49565 A1, 2013 ;
Location in patent: Page/Page column 35-36 ;
反应条件
potassium phosphate; copper(l) iodide; 1,10-phenanthroline in anhydrous xylene; N,N-dimethyl-formamide T=20 - 140°C; 24.1667 h; Inert atmosphere; regioselective reaction;
参考文献
Zhao, Dongbing; Wang, Wenhai; Yang, Fei; Lan, Jingbo; Yang, Li; et al.
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 3296 - 3300
Angewandte Chemie, 2009 , vol. 121, p. 3346 - 3350
反应条件
potassium acetate; palladium diacetate in N,N-dimethyl acetamide T=150°C; Heck reaction; 20 h; Inert atmosphere;
参考文献
Roger, Julien; Pozgan, Franc; Doucet, Henri
Green Chemistry, 2009 , vol. 11, # 3 p. 425 - 432
反应条件
1: 1-formyl-2-chloro-2-(p-methoxyphenyl)ethylene With Na2S*9H2O in N,N-dimethyl-formamide T=60°C; 2 h; 2: monochloroacetaldehyde in N,N-dimethyl-formamide T=60°C; 3 h; 3: With potassium carbonate in water; N,N-dimethyl-formamide T=60°C; 0.166667 h;
参考文献
Herbivo, Cyril; Comel, Alain; Kirsch; Fonseca, A. Mauricio C.; Belsley, M.; Raposo, M. Manuela M.
Dyes and Pigments, 2010 , vol. 86, # 3 p. 217 - 226
反应条件
1: 4-methoxyphenyl magnesium bromide With bismuth(III) chloride 2: 5-Bromothiophene-2-carboxaldehyde With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether T=80°C; Suzuki cross-coupling; 24 h;
参考文献
Costa, Susana P. G.; Batista, Rosa M. F.; Cardoso, Paulo; Belsley, Michael; Raposo, Maria Manuela M.
European Journal of Organic Chemistry, 2006 , # 17 p. 3938 - 3946
反应条件
tetrafluoroboric acid; tri-tert-butyl phosphine; caesium carbonate; palladium diacetate in N,N-dimethyl-formamide T=90°C; Suzuki reaction; 12 h; Product distribution; Further Variations:ReagentsCatalystsSolvents;
参考文献
Handy, Scott T.; Mayi, Diyar
Tetrahedron Letters, 2007 , vol. 48, # 46 p. 8108 - 8110
反应条件
1: 59 percent / Pd(DBA),TPP / tetrahydrofuran / 16 h / Heating 2: 1) n-BuLi / 1) THF, 0 deg C, 1h, 2) r.t., 16 h View Scheme
参考文献
Mignani; Leising; Meyrueix; Samson
Tetrahedron Letters, 1990 , vol. 31, # 33 p. 4743 - 4746
反应条件
n-butyllithium 1) THF, 0 deg C, 1h, 2) r.t., 16 h; Yield given. Multistep reaction;
参考文献
Mignani; Leising; Meyrueix; Samson
Tetrahedron Letters, 1990 , vol. 31, # 33 p. 4743 - 4746
