5-(4-溴苯基)噻吩-2-甲醛合成路线 （共 10 条）
反应条件
sodium carbonate; bis-triphenylphosphine-palladium(II) chloride in ethylene glycol dimethyl ether; ethanol
T=50°C; 3 h; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; BUENO-CALDERON, Jose Maria; FERNANDEZ-MOLINA, Jorge; LEON-DIAZ, Maria Luisa; MALLO-RUBIO, Araceli; MANZANO-CHINCHON, M Pilar
Patent: WO2010/81904 A1, 2010 ;
Location in patent: Page/Page column 42-43 ;
反应条件
1.1: AlCl3 / CS2 / 2.5 h / 20 °C
2.1: dimethylformamide / 22 h / 5 °C
3.1: H2SO4 / methanol / 1 h / Heating
3.2: chloranil / benzene / 2 h / Heating
4.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: dimethylformamide / 22 h / 5 °C
2.1: H2SO4 / methanol / 1 h / Heating
2.2: chloranil / benzene / 2 h / Heating
3.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: H2SO4 / methanol / 1 h / Heating
1.2: chloranil / benzene / 2 h / Heating
2.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
trichlorophosphate in 1,2-dichloro-ethane
Vilsmeier reaction; 17 h; Heating;
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: 76 percent / NaOH; Ag2O / H2O / 20 - 50 °C
2: 83 percent / H2SO4 / toluene / 7 h / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: 76 percent / NaOH; Ag2O / H2O / 20 - 50 °C
2: 83 percent / H2SO4 / toluene / 7 h / Heating
3: LiAlH4 / diethyl ether / Heating
4: HMPA; thionyl chloride / tetrahydrofuran / 20 °C
5: 18-crown-6 / acetonitrile / 20 °C
6: KOH / ethanol; H2O / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: 76 percent / NaOH; Ag2O / H2O / 20 - 50 °C
2: 83 percent / H2SO4 / toluene / 7 h / Heating
3: LiAlH4 / diethyl ether / Heating
4: HMPA; thionyl chloride / tetrahydrofuran / 20 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: 76 percent / NaOH; Ag2O / H2O / 20 - 50 °C
2: 83 percent / H2SO4 / toluene / 7 h / Heating
3: LiAlH4 / diethyl ether / Heating
4: HMPA; thionyl chloride / tetrahydrofuran / 20 °C
5: 18-crown-6 / acetonitrile / 20 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
sodium hydroxide; silver(l) oxide in water
T=20 - 50°C;
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
