5-(4-氯苯基)噻吩-2-甲醛合成路线 （共 11 条）
反应条件
1: 86 percent / NaOH; Ag2O / H2O / 20 - 50 °C
2: 86 percent / H2SO4 / toluene / 7 h / Heating
3: LiAlH4 / diethyl ether / Heating
4: HMPA; thionyl chloride / tetrahydrofuran / 20 °C
5: 18-crown-6 / acetonitrile / 20 °C
6: KOH / ethanol; H2O / Heating
7: 67 percent / H2SO4 / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
