2-乙基-1,6-二噁螺[4.4]-壬烷合成路线 （共 18 条）
反应条件
1: 57 percent / hydrogen / Raney nickel / methanol / 150 °C / 83600 Torr 2: 89 percent / pyridine / 12 h / 20 °C 3: 1.) sulfuryl chloride, Et3N, 2.) methaanol, 3.) MeONa / 1.) methylene chloride, 0 deg C, 1 h; 20 deg C, 1 h, 2.) 20 deg c, 2 h, 3.) reflux, 2 h View Scheme
参考文献
Til' et al.
Zhurnal Obshchei Khimii, 1957 , vol. 27, p. 110,111, 112; engl. Ausg. S. 125, 127
反应条件
hydrogen cation Yield given. Multistep reaction;
参考文献
Mudryk, Boguslaw; Shook, Craig A.; Cohen, Theodore
Journal of the American Chemical Society, 1990 , vol. 112, # 17 p. 6389 - 6391
反应条件
1: 93 percent / pyridine / CH2Cl2 / 0.5 h / Ambient temperature 2: 1) SnCl4 / 1) CH2Cl2, -8 deg C, 15 min, 2) up to 3 deg C, 1 h 3: 92 percent / NaBH4 / ethanol / 12 h / Ambient temperature 4: 39 percent / Raney-Ni W-2 / ethanol; H2O / Heating View Scheme
参考文献
Noe, Christian R.; Knollmueller, Max; Dungler, Karin; Gaertner, Peter
Monatshefte fuer Chemie, 1991 , vol. 122, # 3 p. 185 - 194
反应条件
calcium carbonate in benzene 5 h; Heating;
参考文献
Balea, Ana; Pojar-fenesan, Maria; Pop, Lidia; Oprean, Ioan; Ciupe, Hilke
Revue Roumaine de Chimie, 2002 , vol. 47, # 5 p. 465 - 469
反应条件
1: 80 percent / EtONa / ethanol / 1.) 20 deg C, 1 h, 2.) reflux, 3 h 2: 78 percent / Na2CO3 / dimethylformamide / 3 h / Heating 3: 91 percent / NaBH4 / methanol / 1 h / 20 °C 4: 89 percent / pyridine / 12 h / 20 °C 5: 1.) sulfuryl chloride, Et3N, 2.) methaanol, 3.) MeONa / 1.) methylene chloride, 0 deg C, 1 h; 20 deg C, 1 h, 2.) 20 deg c, 2 h, 3.) reflux, 2 h View Scheme
参考文献
Kozhich, O. A.; Segal', G. M.; Torgov, I. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 2 p. 293 - 295
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 2 p. 325 - 328
反应条件
lithium 1.) ether, -10 deg C to -15 deg C, 3 h, 2.) reflux, 16 h; Yield given. Multistep reaction;
参考文献
Jacobson, Roy; Taylor, Robert J.; Williams, Howard J.; Smith, Leverett R.
Journal of Organic Chemistry, 1982 , vol. 47, # 16 p. 3140 - 3142
反应条件
methanol; sulfuryl dichloride; sodium methylate; triethylamine 1.) methylene chloride, 0 deg C, 1 h; 20 deg C, 1 h, 2.) 20 deg c, 2 h, 3.) reflux, 2 h; Yield given. Multistep reaction;
参考文献
Kozhich, O. A.; Segal', G. M.; Torgov, I. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 2 p. 293 - 295
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 2 p. 325 - 328
反应条件
1: 89 percent / pyridine / 12 h / 20 °C 2: 1.) sulfuryl chloride, Et3N, 2.) methaanol, 3.) MeONa / 1.) methylene chloride, 0 deg C, 1 h; 20 deg C, 1 h, 2.) 20 deg c, 2 h, 3.) reflux, 2 h View Scheme
参考文献
Kozhich, O. A.; Segal', G. M.; Torgov, I. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1982 , vol. 31, # 2 p. 293 - 295
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1982 , # 2 p. 325 - 328
