3,4-二甲基苯甲酸甲酯合成路线 （共 21 条）
反应条件
1: NBS; benzoyl peroxide / CCl4 / Heating 2: Et3N / benzene / Heating 3: LiAlH4 / tetrahydrofuran / 25 °C 4: 86 percent / H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 5: 94 percent / Et3N / CH2Cl2 / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
N-bromosuccinmide; dibenzoyl peroxide in dimethyl sulfoxide
参考文献
Hou, Duen-Ren; Wang, Ming-Shiang; Chung, Ming-Wen; Hsieh, Yih-Dar; Tsai, Hui-Hsu Gavin
Journal of Organic Chemistry, 2007 , vol. 72, # 24 p. 9231 - 9239
反应条件
N-bromosuccinmide; dibenzoyl peroxide
参考文献
Wakunaga Seiyaku Kabushiki Kaisha
Patent: US5026856 A1, 1991 ;
反应条件
1: NBS; benzoyl peroxide / CCl4 / Heating 2: Et3N / benzene / Heating 3: LiAlH4 / tetrahydrofuran / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: NBS; benzoyl peroxide / CCl4 / Heating 2: Et3N / benzene / Heating 3: LiAlH4 / tetrahydrofuran / 25 °C 4: 86 percent / H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: 99 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h, 2.) room temp., overnight 2: 95 percent / SOCl2, pyridine / benzene / 20 h / Ambient temperature View Scheme
参考文献
Gready, Jill E.; Hambley, Trevor W.; Kakiuchi, Kiyomi; Kobiro, Kazuya; Sternhell, Sever; Tansey, Charles W.; Tobe, Yoshito
Journal of the American Chemical Society, 1990 , vol. 112, # 21 p. 7537 - 7540
反应条件
lithium aluminium tetrahydride in diethyl ether 1.) reflux, 3 h, 2.) room temp., overnight;
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 185 - 200
反应条件
1: 99 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h, 2.) room temp., overnight 2: 83 percent / PCC / CH2Cl2 / 2 h / Ambient temperature 3: 92.2 percent / pyridine, piperidine / 48 h / 80 °C 4: 98.2 percent / H2 / 10percent Pd/C / dioxane / 517.1 - 1551.4 Torr View Scheme
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 185 - 200
反应条件
1: 99 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h, 2.) room temp., overnight 2: 83 percent / PCC / CH2Cl2 / 2 h / Ambient temperature 3: 92.2 percent / pyridine, piperidine / 48 h / 80 °C 4: 98.2 percent / H2 / 10percent Pd/C / dioxane / 517.1 - 1551.4 Torr 5: 36.4 percent / polyphosphoric acid / 2.5 h / 70 °C View Scheme
参考文献
Monatshefte fur Chemie, , vol. 127, # 2 p. 185 - 200
反应条件
1: 99 percent / LiAlH4 / diethyl ether / 1.) reflux, 3 h, 2.) room temp., overnight
2: 83 percent / PCC / CH2Cl2 / 2 h / Ambient temperature
3: 92.2 percent / pyridine, piperidine / 48 h / 80 °C
4: 98.2 percent / H2 / 10percent Pd/C / dioxane / 517.1 - 1551.4 Torr
5: polyphosphoric acid / 2.5 h / 70 °C
View Scheme
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 185 - 200
